Dartmouth/Boston University AITRP

描述（由申请人提供）：达特茅斯/波士顿大学（BU）艾滋病国际培训和研究项目（AITRP）在其第一个5年周期中产生的影响远远超过了项目计划中所定义的：11名学员参加了学位课程（3名博士和3名硕士），11名参加了短期培训，320名参加了坦桑尼亚的会议。所有受训人员都返回坦桑尼亚或承诺在培训结束后返回。总的来说，这些项目加强了Muhimbili大学健康科学学院（MUCHS）艾滋病和结核病研究能力的发展，并影响了坦桑尼亚的艾滋病和结核病政策。该项目不仅培养了达特茅斯学院教师对坦桑尼亚艾滋病研究的兴趣，还促成了达特茅斯学院与坦桑尼亚国立卫生研究院之间的正式谅解备忘录，为坦桑尼亚艾滋病和结核病研究提供长期支持。在拟议的5年续期中，参与机构将根据最初周期的经验教训和与卫生部规划（艾滋病和结核病）以及主要国际机构和基金会官员进行的需求评估，扩大其艾滋病研究合作的范围和深度；还计划与这些实体中的每一个以及坦桑尼亚和乌干达的其他aitrp扩大伙伴关系。此次更新将进一步侧重于艾滋病毒相关结核病的关键研究重点（包括创新诊断、免疫反应、临床试验和实施科学）和艾滋病毒粘膜免疫学。此外，重点领域将扩大到包括艾滋病毒、儿童艾滋病毒和艾滋病毒母乳传播的疫苗研究。将与病例-乌干达AITRP和坦桑尼亚的其他AITRP合作，建立一个新的东非艾滋病毒和结核病联盟。6-10年级项目将为2名学员提供博士学位，7名学员提供硕士学位，2名学员提供博士后培训，22名学员在国外或坦桑尼亚进行短期培训，6名学员在坦桑尼亚进行高级研究支持。此外，每年将在达累斯萨拉姆举行两次aitrp赞助的培训会议，并将向250-500名额外的研究人员和保健专业人员提供培训。由此产生的培训和相关研究的最终目标是降低艾滋病毒和结核病的发病率和死亡率。

DESCRIPTION (provided by applicant): In its first 5 year cycle, the Dartmouth /Boston University (BU) AIDS International Training and Research Program (AITRP) had effects far exceeding those defined in the Program Plan: 11 trainees participated in degree programs (3 doctoral and 3 MPH), 11 in short term training and 320 in conferences in Tanzania. All trainees returned to Tanzania or are committed to return at the end of their training. Collectively, these programs enhanced the development of AIDS and tuberculosis (TB) research capacity at the Muhimbili University College of Health Sciences (MUCHS), and influenced AIDS and TB policies in Tanzania. The Program not only fostered the interests of Dartmouth faculty in AIDS research in Tanzania, but led to a formal Memorandum of Understanding between Dartmouth and MUCHS for long term support of AIDS and TB research in Tanzania. In the proposed 5 year renewal the participating institutions will increase the scope and depth of their AIDS research collaborations based on lessons learned in the initial cycle and a needs assessment conducted with officials at MUCHS, Ministry of Health programs (AIDS, TB), and key international agencies and foundations; expanded partnerships are also planned with each of these entities and with other AITRPs in Tanzania and Uganda. The renewal will focus further on the critical research priority of HIV-associated tuberculosis (including innovative diagnostics, immune response, clinical trials and implementation science) and mucosal immunology of HIV. In addition, areas of concentration will be expanded to include vaccine research in HIV, pediatric HIV, and breast milk transmission of HIV. A new East Africa Consortium on HIV and TB will be established in partnership with the Case-Uganda AITRP and other AITRPs in Tanzania. The year 6-10 program will provide PhD degrees to 2 trainees, MPH degrees to 7, post doctoral training to 2, short term training abroad or in Tanzania to 22, and advanced research support in Tanzania to 6 trainees. In addition two AITRP-sponsored training conferences will be held in Dar es Salaam each year and will provide training to 250-500 additional researchers and health care professionals. The ultimate goal of the resultant training and the associated research is reduction in morbidity and mortality due to HIV and tuberculosis.