Tuberculosis Research Institute at MUHAS

MUHAS 结核病研究所

• 批准号: 8514831
• 负责人: Charles Fordham von Reyn
• 金额: $ 27.46万
• 依托单位: DARTMOUTH COLLEGE
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-08-01 至 2018-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8514831
• 关键词: Adult; Advertising; Advisory Committees; African; Boston; Cause of Death; Childhood; Clinical; Complex; Development; Doctor' s Degree; Epidemiology; Ethics; Faculty; Funding; Good Clinical Practice; Grant; HIV; HIV Infections; Health Sciences; Immunology; Institutes; Laboratories; Leadership; Leprosy; Link; Master' s Degree; Measures; Mentors; Microbiology; Monitor; Performance; Persons; Pharmacology; Prevention; Public Health; Recruitment Activity; Research; Research Institute; Research Methodology; Research Personnel; Research Priority; Research Project Grants; Secure; Students; TRIM Gene; Tanzania; Teleconferences; Training; Tuberculosis; Universities; base; clinical research site; experience; improved; pediatric human immunodeficiency virus; performance site; programs

Tuberculosis is the leading cause of death among persons with HIV infection in Tanzania. Clinical and operational research to improve prevention and treatment of both adult and pediatric HIV-TB is a defined national priority but there is no specifically designated and staffed institute to plan, coordinate and conduct such research. The objective of the Dartmouth-Boston University (DBU) application is to provide the training to develop a premier HIV-TB clinical and operational research institute: the Tuberculosis Research Institute at Muhimibili University of Health and Allied Sciences (MUHAS) (TRIM- TB). MUHAS leadership, the Tanzanian National Tuberculosis and Leprosy Program (NTLP) and former Fogarty trainees have all contributed to planning the new institute. The program will consolidate the expertise of past Fogarty trainees with a new focused plan to train the requisite professionals to fully staff TRIM-TB. The institute will be based a new office complex at MUHAS with additional staffing located at the NTLP. An initial faculty core at MUHAS (Director, Associate Director) will be augmented by the addition of trainees who will complete the following degrees determined to be necessary for providing the necessary research expertise for the institute: 3 MPH degrees at Dartmouth, 3 MPH degrees at MUHAS, 1 master's degree at BU (pharmacology) and 2 doctoral degrees at BU (epidemiology, public health). Additional short and medium term training in ethics, good clinical practice and HIV-TB research methods will be provided for investigators. Advanced TB microbiology and TB immunology training will be provided for research microbiologists who will staff the TRIM-TB core laboratory. Pilot grant funding will be available for HIV-TB research projects and investigators will coordinate efforts thru monthly research seminars at MUHAS linked by teleconference to Dartmouth and BU. Defined performance measures focused on development of independent HIV-TB research capacity have been developed and will be monitored. An extensive candidate pool will be recruited from health science students at MUHAS, prior DBU AITRP trainees, Fogarty alumni, public presentations and focused advertising. Performance sites for research will include adult and pediatric DarDar Programs, NTLP clinical sites, and the Fogarty African Consortium on Tuberculosis (FACT, developed by the DBU AITRP). Faculty for the program have extensive experience in HIV-TB research, actively funded research projects, and wide experience training and mentoring junior colleagues. An expert Training Advisory Committee will oversee the program. After 5 years TRIM-TB will have set HIV-TB research priorities for Tanzania and have secured independent funding for research on these priorities.

结核病是坦桑尼亚艾滋病毒感染者死亡的主要原因。临床和