Tuberculosis Research Institute at MUHAS

结核病是坦桑尼亚艾滋病毒感染者的主要死因。临床和 改进成人和儿童艾滋病毒-结核病预防和治疗的业务研究是一项 确定了国家优先事项，但没有专门指定和配备人员的机构来规划、协调 并进行这样的研究。达特茅斯-波士顿大学(DBU)申请的目标是 提供培训，以发展一流的艾滋病毒-结核病临床和操作研究机构： 穆希米比利卫生与相关科学大学结核病研究所(TRIM- 结核病)。MUHAS领导层、坦桑尼亚国家结核病和麻风病方案(NTLP)和 前Fogarty实习生都为新学院的规划做出了贡献。 该计划将巩固过去Fogarty学员的专业知识，并制定新的重点计划，培训 必要的专业人员为TRIM-TB配备充分的工作人员。该研究所将把一个新的办公大楼设在 MUHAS，在NTLP增加了工作人员。MUHAS最初的教员核心(主任、 副主任)将通过增加完成以下任务的受训人员而得到加强 确定为研究所提供必要的研究专门知识所需的学位：3 达特茅斯大学公共卫生硕士学位，密歇根州立大学3英里每小时学位，北卡罗来纳大学1个硕士学位(药理学)和 BU(流行病学、公共卫生)2个博士学位。额外的短期和中期培训 将为研究人员提供道德规范、良好的临床实践和艾滋病毒-结核病研究方法。进阶 将为研究微生物学家提供结核病微生物学和结核病免疫学培训，他们将为 TRIM-TB核心实验室。将为艾滋病毒-结核病研究项目提供试点赠款资金，并 调查人员将通过每月通过电话会议连接的MUHAS研究研讨会来协调工作 去达特茅斯大学和波士顿大学。明确的业绩衡量标准侧重于发展独立的艾滋病毒-结核病 已经发展了研究能力，并将对其进行监测。 将从MUHAS，以前的DBU健康科学专业的学生中招募大量的应聘者 AITRP实习生、Fogarty校友、公开演讲和有针对性的广告。性能站点用于 研究将包括成人和儿童DarDar计划、NTLP临床站点和Fogarty非洲 结核病问题联合会(FACT，由DBU AITRP制定)。该项目的教职员工有 在艾滋病毒-结核病研究方面有丰富的经验，积极资助的研究项目，以及广泛的经验 培训和指导初级同事。一个专家培训咨询委员会将监督 程序。5年后，Trim-TB将为坦桑尼亚设定艾滋病毒-结核病研究的优先事项，并已 确保了对这些优先事项的研究的独立资金。

Tuberculosis is the leading cause of death among persons with HIV infection in Tanzania. Clinical and operational research to improve prevention and treatment of both adult and pediatric HIV-TB is a defined national priority but there is no specifically designated and staffed institute to plan, coordinate and conduct such research. The objective of the Dartmouth-Boston University (DBU) application is to provide the training to develop a premier HIV-TB clinical and operational research institute: the Tuberculosis Research Institute at Muhimibili University of Health and Allied Sciences (MUHAS) (TRIM- TB). MUHAS leadership, the Tanzanian National Tuberculosis and Leprosy Program (NTLP) and former Fogarty trainees have all contributed to planning the new institute. The program will consolidate the expertise of past Fogarty trainees with a new focused plan to train the requisite professionals to fully staff TRIM-TB. The institute will be based a new office complex at MUHAS with additional staffing located at the NTLP. An initial faculty core at MUHAS (Director, Associate Director) will be augmented by the addition of trainees who will complete the following degrees determined to be necessary for providing the necessary research expertise for the institute: 3 MPH degrees at Dartmouth, 3 MPH degrees at MUHAS, 1 master's degree at BU (pharmacology) and 2 doctoral degrees at BU (epidemiology, public health). Additional short and medium term training in ethics, good clinical practice and HIV-TB research methods will be provided for investigators. Advanced TB microbiology and TB immunology training will be provided for research microbiologists who will staff the TRIM-TB core laboratory. Pilot grant funding will be available for HIV-TB research projects and investigators will coordinate efforts thru monthly research seminars at MUHAS linked by teleconference to Dartmouth and BU. Defined performance measures focused on development of independent HIV-TB research capacity have been developed and will be monitored. An extensive candidate pool will be recruited from health science students at MUHAS, prior DBU AITRP trainees, Fogarty alumni, public presentations and focused advertising. Performance sites for research will include adult and pediatric DarDar Programs, NTLP clinical sites, and the Fogarty African Consortium on Tuberculosis (FACT, developed by the DBU AITRP). Faculty for the program have extensive experience in HIV-TB research, actively funded research projects, and wide experience training and mentoring junior colleagues. An expert Training Advisory Committee will oversee the program. After 5 years TRIM-TB will have set HIV-TB research priorities for Tanzania and have secured independent funding for research on these priorities.