Tuberculosis Research Institute at MUHAS

结核病是坦桑尼亚艾滋病毒感染者死亡的主要原因。临床和 改善成人和儿童艾滋病毒结核病预防和治疗的业务研究是一项 确定了国家优先事项，但没有专门指定和配备人员的机构来规划、协调 进行这样的研究。达特茅斯-波士顿大学（DBU）申请的目的是 提供培训，以建立一个一流的艾滋病毒-结核病临床和业务研究机构： Muhimibili卫生和相关科学大学结核病研究所（TRIM- TB）。MUHAS领导，坦桑尼亚国家结核病和麻风病方案（NTLP）， 前福格蒂学员都为新学院的规划做出了贡献。 该计划将巩固过去福格蒂学员的专业知识，并制定一项新的重点计划， 为《与贸易有关的投资措施-结核病》配备所需的专业人员。该研究所将设在一个新的办公大楼， MUHAS与位于NTLP的额外工作人员。MUHAS的初始教师核心（主任， 助理主任）将增加受训人员，他们将完成以下工作 确定为研究所提供必要的研究专门知识所需的学位：3 达特茅斯的MPH学位，MUHAS的3个MPH学位，BU（药理学）的1个硕士学位， 2个BU博士学位（流行病学，公共卫生）。短期和中期培训 将为研究者提供伦理、良好临床实践和艾滋病毒-结核病研究方法。先进 结核病微生物学和结核病免疫学培训将提供给研究微生物学家， TRIM-TB核心实验室。试点赠款资金将用于艾滋病毒结核病研究项目， 研究人员将通过每月在MUHAS举行的研究研讨会协调工作，研讨会通过电话会议联系起来 到达特茅斯和波士顿大学确定的绩效衡量标准侧重于独立的艾滋病毒/结核病的发展 研究能力已经发展，并将予以监测。 一个广泛的候选人库将从MUHAS的健康科学学生中招募，之前DBU AITRP学员，福格蒂校友，公开演讲和重点广告。表演场地 研究将包括成人和儿科DarDar计划，NTLP临床站点和Fogarty非洲 结核病联盟（FACT，由DBU AITRP开发）。该计划的教师有 在艾滋病毒-结核病研究方面的丰富经验，积极资助的研究项目，以及广泛的经验 培训和指导初级同事。一个专家培训咨询委员会将监督 程序. 5年后，TRIM-TB将为坦桑尼亚确定艾滋病毒结核病研究的优先事项， 为这些优先事项的研究获得了独立的资金。

Tuberculosis is the leading cause of death among persons with HIV infection in Tanzania. Clinical and operational research to improve prevention and treatment of both adult and pediatric HIV-TB is a defined national priority but there is no specifically designated and staffed institute to plan, coordinate and conduct such research. The objective of the Dartmouth-Boston University (DBU) application is to provide the training to develop a premier HIV-TB clinical and operational research institute: the Tuberculosis Research Institute at Muhimibili University of Health and Allied Sciences (MUHAS) (TRIM- TB). MUHAS leadership, the Tanzanian National Tuberculosis and Leprosy Program (NTLP) and former Fogarty trainees have all contributed to planning the new institute. The program will consolidate the expertise of past Fogarty trainees with a new focused plan to train the requisite professionals to fully staff TRIM-TB. The institute will be based a new office complex at MUHAS with additional staffing located at the NTLP. An initial faculty core at MUHAS (Director, Associate Director) will be augmented by the addition of trainees who will complete the following degrees determined to be necessary for providing the necessary research expertise for the institute: 3 MPH degrees at Dartmouth, 3 MPH degrees at MUHAS, 1 master's degree at BU (pharmacology) and 2 doctoral degrees at BU (epidemiology, public health). Additional short and medium term training in ethics, good clinical practice and HIV-TB research methods will be provided for investigators. Advanced TB microbiology and TB immunology training will be provided for research microbiologists who will staff the TRIM-TB core laboratory. Pilot grant funding will be available for HIV-TB research projects and investigators will coordinate efforts thru monthly research seminars at MUHAS linked by teleconference to Dartmouth and BU. Defined performance measures focused on development of independent HIV-TB research capacity have been developed and will be monitored. An extensive candidate pool will be recruited from health science students at MUHAS, prior DBU AITRP trainees, Fogarty alumni, public presentations and focused advertising. Performance sites for research will include adult and pediatric DarDar Programs, NTLP clinical sites, and the Fogarty African Consortium on Tuberculosis (FACT, developed by the DBU AITRP). Faculty for the program have extensive experience in HIV-TB research, actively funded research projects, and wide experience training and mentoring junior colleagues. An expert Training Advisory Committee will oversee the program. After 5 years TRIM-TB will have set HIV-TB research priorities for Tanzania and have secured independent funding for research on these priorities.