Tuberculosis Research Institute at MUHAS

说明（由申请人提供）：结核病是坦桑尼亚艾滋病毒感染者死亡的主要原因。改善成人和儿童艾滋病毒-结核预防和治疗的临床和业务研究是确定的国家优先事项，但没有专门指定和配备人员的研究所来规划、协调和开展此类研究。达特茅斯-波士顿大学（DBU）申请的目标是提供培训，以建立一个一流的艾滋病毒-结核病临床和业务研究所：MUHAS领导层、坦桑尼亚国家结核病和麻风病计划（NTLP）和前福格蒂学员都为新研究所的规划做出了贡献。该方案将通过一项新的重点计划巩固过去福格蒂受训人员的专业知识，培训必要的专业人员，使trimt - tb全面配备人员。该研究所将设在MUHAS的一个新的办公大楼，并在NTLP增加工作人员。MUHAS最初的教师核心（主任、副主任）将通过增加学员来增加，这些学员将完成以下学位，这些学位被认为是为研究所提供必要的研究专业知识所必需的：达特茅斯学院的3个MPH学位，MUHAS的3个MPH学位，波士顿大学的1个硕士学位（药理学）和波士顿大学的2个博士学位（流行病学、公共卫生）。将为研究人员提供关于伦理、良好临床实践和艾滋病毒-结核病研究方法的额外短期和中期培训。将为trimm -TB核心实验室的研究微生物学家提供高级结核微生物学和结核免疫学培训。试点资助将用于艾滋病-结核病研究项目，研究人员将通过每月在MUHAS举行的研究研讨会与达特茅斯大学和波士顿大学通过电话会议进行协调。已经制定了侧重于发展独立的艾滋病毒-结核病研究能力的明确绩效衡量标准，并将对其进行监测。广泛的候选人将从MUHAS的健康科学学生、DBU AITRP之前的学员、Fogarty校友、公开演讲和重点广告中招募。研究的执行地点将包括成人和儿童DarDar项目、NTLP临床地点和福格蒂非洲结核病联盟（FACT，由DBU AITRP开发）。该计划的教员在艾滋病毒-结核病研究方面拥有丰富的经验，积极资助的研究项目，以及培训和指导初级同事的丰富经验。一个专家培训咨询委员会将监督该计划。5年后，trimt - tb将为坦桑尼亚确定艾滋病毒-结核病研究优先事项，并为这些优先事项的研究获得独立资助。

DESCRIPTION (provided by applicant): Tuberculosis is the leading cause of death among persons with HIV infection in Tanzania. Clinical and operational research to improve prevention and treatment of both adult and pediatric HIV-TB is a defined national priority but there is no specifically designated and staffed institute to plan, coordinate and conduct such research. The objective of the Dartmouth-Boston University (DBU) application is to provide the training to develop a premier HIV-TB clinical and operational research institute: MUHAS leadership, the Tanzanian National Tuberculosis and Leprosy Program (NTLP) and former Fogarty trainees have all contributed to planning the new institute. The program will consolidate the expertise of past Fogarty trainees with a new focused plan to train the requisite professionals to fully staff TRIM-TB. The institute will be based a new office complex at MUHAS with additional staffing located at the NTLP. An initial faculty core at MUHAS (Director, Associate Director) will be augmented by the addition of trainees who will complete the following degrees determined to be necessary for providing the necessary research expertise for the institute: 3 MPH degrees at Dartmouth, 3 MPH degrees at MUHAS, 1 master's degree at BU (pharmacology) and 2 doctoral degrees at BU (epidemiology, public health). Additional short and medium term training in ethics, good clinical practice and HIV-TB research methods will be provided for investigators. Advanced TB microbiology and TB immunology training will be provided for research microbiologists who will staff the TRIM-TB core laboratory. Pilot grant funding will be available for HIV-TB research projects and investigators will coordinate efforts thru monthly research seminars at MUHAS linked by teleconference to Dartmouth and BU. Defined performance measures focused on development of independent HIV-TB research capacity have been developed and will be monitored. An extensive candidate pool will be recruited from health science students at MUHAS, prior DBU AITRP trainees, Fogarty alumni, public presentations and focused advertising. Performance sites for research will include adult and pediatric DarDar Programs, NTLP clinical sites, and the Fogarty African Consortium on Tuberculosis (FACT, developed by the DBU AITRP). Faculty for the program have extensive experience in HIV-TB research, actively funded research projects, and wide experience training and mentoring junior colleagues. An expert Training Advisory Committee will oversee the program. After 5 years TRIM-TB will have set HIV-TB research priorities for Tanzania and have secured independent funding for research on these priorities.