Tuberculosis Research Institute at MUHAS

描述（由申请人提供）：结核病是坦桑尼亚艾滋病毒感染者的主要死因。改善成人和儿童艾滋病毒/结核病预防和治疗的临床和业务研究是一个明确的国家优先事项，但没有专门指定和配备人员的机构来规划、协调和开展此类研究。达特茅斯-波士顿大学（DBU）申请的目的是提供培训，以建立一个首屈一指的艾滋病毒-结核病临床和业务研究机构：MUHAS领导层，坦桑尼亚国家结核病和麻风病计划（NTLP）和前Fogarty学员都为规划新机构做出了贡献。该计划将巩固过去福格蒂学员的专业知识，并制定一项新的重点计划，培训必要的专业人员，以充分配备TRIM-TB。该研究所将设在MUHAS的一个新的办公大楼内，并在NTLP配备额外的工作人员。MUHAS最初的教师核心（主任，副主任）将通过增加受训人员来增加，这些受训人员将完成为研究所提供必要的研究专业知识所必需的以下学位：达特茅斯的3个MPH学位，MUHAS的3个MPH学位，BU（药理学）的1个硕士学位和BU（流行病学，公共卫生）的2个博士学位。将为研究人员提供伦理、良好临床实践和艾滋病毒-结核病研究方法方面的额外短期和中期培训。将为将在TRIM-TB核心实验室工作的研究微生物学家提供先进的TB微生物学和TB免疫学培训。试点赠款资金将用于艾滋病毒-结核病研究项目，研究人员将通过每月在MUHAS举行的研究研讨会与达特茅斯和BU通过电话会议进行协调。已经制定并将监测侧重于发展独立的艾滋病毒/结核病研究能力的明确业绩衡量标准。一个广泛的候选人库将从MUHAS的健康科学学生，以前的DBU AITRP学员，福格蒂校友，公开演讲和重点广告招募。研究的执行地点将包括成人和儿童DarDar计划，NTLP临床地点和Fogarty非洲结核病联盟（FACT，由DBU AITRP开发）。该计划的教师在艾滋病毒-结核病研究方面拥有丰富的经验，积极资助的研究项目，以及广泛的培训和指导初级同事的经验。一个专家培训咨询委员会将监督该计划。5年后，TRIM-TB将为坦桑尼亚确定艾滋病毒-结核病研究的优先事项，并为这些优先事项的研究获得独立的资金。

DESCRIPTION (provided by applicant): Tuberculosis is the leading cause of death among persons with HIV infection in Tanzania. Clinical and operational research to improve prevention and treatment of both adult and pediatric HIV-TB is a defined national priority but there is no specifically designated and staffed institute to plan, coordinate and conduct such research. The objective of the Dartmouth-Boston University (DBU) application is to provide the training to develop a premier HIV-TB clinical and operational research institute: MUHAS leadership, the Tanzanian National Tuberculosis and Leprosy Program (NTLP) and former Fogarty trainees have all contributed to planning the new institute. The program will consolidate the expertise of past Fogarty trainees with a new focused plan to train the requisite professionals to fully staff TRIM-TB. The institute will be based a new office complex at MUHAS with additional staffing located at the NTLP. An initial faculty core at MUHAS (Director, Associate Director) will be augmented by the addition of trainees who will complete the following degrees determined to be necessary for providing the necessary research expertise for the institute: 3 MPH degrees at Dartmouth, 3 MPH degrees at MUHAS, 1 master's degree at BU (pharmacology) and 2 doctoral degrees at BU (epidemiology, public health). Additional short and medium term training in ethics, good clinical practice and HIV-TB research methods will be provided for investigators. Advanced TB microbiology and TB immunology training will be provided for research microbiologists who will staff the TRIM-TB core laboratory. Pilot grant funding will be available for HIV-TB research projects and investigators will coordinate efforts thru monthly research seminars at MUHAS linked by teleconference to Dartmouth and BU. Defined performance measures focused on development of independent HIV-TB research capacity have been developed and will be monitored. An extensive candidate pool will be recruited from health science students at MUHAS, prior DBU AITRP trainees, Fogarty alumni, public presentations and focused advertising. Performance sites for research will include adult and pediatric DarDar Programs, NTLP clinical sites, and the Fogarty African Consortium on Tuberculosis (FACT, developed by the DBU AITRP). Faculty for the program have extensive experience in HIV-TB research, actively funded research projects, and wide experience training and mentoring junior colleagues. An expert Training Advisory Committee will oversee the program. After 5 years TRIM-TB will have set HIV-TB research priorities for Tanzania and have secured independent funding for research on these priorities.