INTERACT: a randomised trial of intensive blood pressure lowering in acute intracerebral haemorrhage

脑出血（ICH）是一种严重的中风类型，每年影响数千名澳大利亚人和世界上200 - 300万人，其中大多数人要么死亡，要么残疾。目前还没有证实的治疗脑出血的方法，尽管有时会使用手术和早期注射一种特殊的凝血因子可能会改善结果。一种潜在的简单治疗方法是快速控制血压升高（BP），这在脑出血中很常见，可能通过增加脑出血和肿胀来预测预后不良。对于脑出血患者血压升高的最佳处理方法存在很多不确定性。这项名为INTERACT的研究旨在确定早期快速降压管理策略的收益和风险的平衡，该策略随机选择了来自澳大利亚-亚洲100个临床站点的2000名脑出血患者。

Intracerebral haemorrhage (ICH) is a serious type of stroke affecting thousands of Australians and 2-3 million people in the world each year, with most either dying or left disabled. There is no proven treatment for ICH, although surgery is sometimes used and early injection of a special clotting factor may improve outcome. One potential simple therapy is the rapid control of elevated blood pressure (BP) which occurs commonly and predicts a poor outcome in ICH, possibly by increasing bleeding and swelling in the brain. There is much uncertainty as to the optimal management of elevated BP in ICH. This study, called INTERACT, aims to determine the balance of benefits and risks of a management strategy of early rapid BP lowering in 2000 patients with ICH randomised from 100 clinical sites in Australia-Asia.