Protein Structure and Function

该提案要求支持继续发展生物医学研究卓越中心， 蛋白质结构和功能（COBRE-PSF）在堪萨斯大学。我们的中心成立于 2002年10月，包括来自另外三所堪萨斯大学的参与者。五年后，我们所有的 最初的目标已经实现，而且在大多数情况下，大大超过了这些目标。我们已经毕业了九年级 将调查员移交给独立的R01支助，共征聘和支助了15名新的初级调查员 通过替代和试点项目赠款，举办了六次科学讲习班和三次赠款撰写讲习班， 激发了多项研究合作。我们还改造了6000多平方米。英尺的空间，建立了一个新的 17，500平方米英尺的结构生物学中心，成立了一个新的核心致力于生物核磁共振，并制定了计划 把COBRE-PSF变成一个自给自足的研究中心。我们的调查人员已经发表了超过226篇 同行评审的手稿，并已收到69项研究资助总额超过2200万美元。 在续约期间，我们对中心的总体目标是： 1.招募、指导和加速优秀青年科学家的职业发展; 2.提高我们现有的蛋白质生产核心实验室（核心B）的能力; 3.加强现有蛋白质结构实验室（C核心）的能力; 4.建立一个生物核磁共振核心实验室，致力于蛋白质核磁共振研究（核心D）; 5.通过以下方式加速中心所有参与者的专业和科学成长： 研究会议、研讨会、赠款申请写作讲习班和科学讲习班。 我们的长期目标是获得成功的，独立的，但合作的研究人员的临界质量， 专注于蛋白质的结构和功能在健康和疾病，通过它COBRE-PSF将成为一个 自我维持的企业走向未来。 基因组学的巨大进步为识别细胞蛋白质铺平了道路， 最终负责正常细胞功能和潜在疾病状态的功能障碍。 治疗干预的发展始于了解与疾病有关的蛋白质， 这需要在细胞蛋白质研究方面具有杰出专业知识的科学家。

This proposal requests support to continue development of a Center of Biomedical Research Excellence in Protein Structure and Function (COBRE-PSF) at the University of Kansas. Our Center was established in October 2002, and includes participants from three additional Kansas Universities. After five years all of our initial goals have been met and, in most cases, surpassed by a wide margin. We have graduated nine junior investigators to independent R01 support, recruited and supported a total of 15 additional junior investigators through replacement and pilot project grants, held six scientific and three grant-writing workshops, and inspired multiple research collaborations. We also remodeled over 6000 sq. feet of space, built a new 17,500 sq. foot Structural Biology Center, inaugurated a new Core dedicated to Bio-NMR, and enacted plans to move COBRE-PSF toward a self-sustaining research center. Our investigators have published over 226 peer-reviewed manuscripts and have received 69 research grants totaling more than $22 M. For the renewal period, our overall Aims for the Center are: 1. To recruit, mentor, and accelerate the career development of outstanding junior scientists; 2. To enhance the capabilities of our existing Protein Production Core Laboratory (Core B); 3. To enhance the capabilities of our existing Protein Structure Laboratory (Core C); 4. To build a Bio-NMR Core Laboratory dedicated to Protein NMR studies (Core D); 5. To accelerate the professional and scientific growth of all Center participants through a combination of research meetings, seminars, grant application writing workshops, and scientific workshops. Our long-term goal is to attain a critical mass of successful, independent but collaborative investigators, focused on protein structure and function in health and disease, through which COBRE-PSF will become a self-sustaining enterprise into the future. Lay statement: Great advances in genomics paved the way for identifying the cellular proteins that are ultimately responsible for normal cell functioning and for the dysfunction underlying disease states. Development of therapeutic interventions begins with understanding the proteins involved in diseases, and this requires scientists with outstanding expertise in the study of cellular proteins.