Graduate Training in Molecular Biology and Biophysics

描述(由申请人提供)：俄勒冈大学正在进行的分子生物学和生物物理学研究生研究培训项目需要继续提供支持。这次培训活动以分子生物学研究所为中心，还涉及 其他具有相关科学兴趣的小组。在一个包括大约59名研究生、47名博士后实习生和22名培训教师的项目中，需要为12个博士后职位申请资金。该计划特别强调基因表达和核酸结构/功能的控制，信号和细胞功能的分子基础，蛋白质结构和动力学，以及发育和分化的分子方法。培训的基本方面是在分子生物学和生物物理学培训计划中在一名教员的指导下进行的实验室研究。通过这种经历，学员能够熟练地提出有关基本生物过程的问题，并设计实验来回答这些问题。通过生物、化学和物理系提供的正式课程，通过突出分子生物学、生物物理学和相关学科的当前研究的研讨会计划，通过论文咨询委员会的密切参与，以及通过研究研讨会和受训人员的期刊俱乐部演讲，培训得到了加强。培训设施包括教员的实验室和支持服务，如结构生物学生物物理设施、最先进的基因组学 和成像设施，以及一大批其他现代化设施。主要设备共享并安置在公共空间中。大多数教员的实验室都是毗连的，在相互连接的大楼里。这种安排促进了教职员工和学生之间强有力的跨学科互动和合作。 公共卫生相关性：该提案旨在为分子生物学和生物物理学博士学位的研究生培训提供支持。我们的目标是培养富有创造力、对智力具有批判性和实验技能的生物科学家。我们认为，实现这一目标的培训首先是在实验室完成的，培训的重点是学习为一个重要的科学问题找到严格的实验答案。该培训计划积极促进跨学科和协作科学的发展。我们希望我们的学生发展成为富有想象力和能力的研究科学家，具备领导自己的研究项目的知识，从而加强这一领域的国家资源。

DESCRIPTION (provided by applicant): Continued support is requested for an ongoing program of graduate research training in molecular biology and biophysics at the University of Oregon. This training activity is centered in the Institute of Molecular Biology, and also involves additional groups with related scientific interests. Funds are requested for 12 predoctoral positions, within a program that includes approximately 59 graduate students, 47 postdoctoral trainees, and 22 training faculty. The program places special emphasis on the control of gene expression and nucleic acid structure/function, molecular basis of signaling and cell function, protein structure and dynamics, and molecular approaches to development and differentiation. The basic aspect of the training is laboratory research carried out under the direction of a facult member in the molecular biology and biophysics training program. Through this experience, the trainee becomes skilled at posing questions about fundamental biological processes and designing experiments to answer those questions. The training is augmented by formal courses offered by the Biology, Chemistry, and Physics Departments, by seminar programs that highlight current research in molecular biology, biophysics, and related disciplines, by the close involvement of a Thesis Advisory Committee, and by research seminar and journal club presentations by trainees. The training facilities include the laboratories of the faculty and support services such as the structural biology biophysical facility, the state-of-the-art genomics and imaging facilities, and a large number of other modern facilities. Major equipment is shared and housed in common space. The laboratories of most of the faculty are contiguous and in interconnected buildings. This arrangement fosters strong interdisciplinary interactions and collaborations among faculty and students. PUBLIC HEALTH RELEVANCE: This proposal is to provide support for graduate training leading to the Ph.D. degree in molecular biology and biophysics. Our goal is to produce creative, intellectually critical, and experimentally skilled bioscientists. We believe that trainig towards this end is first and foremost accomplished at the laboratory bench, and training is focused on learning to find a rigorous experimental answer to a significant scientific question. The training program actively promotes strongly interdisciplinary and collaborative science. We want our students to develop into imaginative and capable research scientists, equipped with the knowledge to lead research programs of their own, thereby strengthening the national resource in this area.