Interdepartmental Training in Pharmacological Sciences

描述（由申请人提供）：密歇根大学药理科学和生物相关化学培训计划（PSTP）为博士前学生提供基本药理学原理的坚实基础和其他生物相关基础科学学科的广泛知识（例如，药物化学）。所有学生都将完成一门核心课程，包括药理学，药物化学，生理学和生物统计学课程，以及其他旨在满足个别学生课程需求的选修课程。学生可以遵循两个一般轨道之一，重点是生物或化学研究。该计划的研究集中领域包括心血管/肾脏药理学，神经药理学，异生物质代谢，生长和代谢调节，受体结构和功能，治疗和诊断药物的合成和药理学，抗生素发现，酶学，运输机制，药物吸收，药物输送和药代动力学。学生获得几种类型的药理学研究的实验室经验，并学习如何设计实验，评估实验数据，并使用适当的统计方法。培训计划包括研究生课程;负责进行研究的培训;研讨会课程;资格考试;职业和专业发展活动（新提交）;在年度研讨会上进行必要的研究报告;监督实验室调查，导致学生的博士论文和最后的口头考试，在此期间，受训者捍卫他的/在他们的论文委员会面前展示她的论文高素质的学生，有兴趣获得药理学科学的高级培训，通常不会提供给他们在他们的博士课程，由他们的博士课程提名到PSTP。他们的教师导师必须是PSTP的成员。从2010-11年开始，所有被提名参加PSTP的学生都将由预选委员会进行审查，该委员会将根据学生的研究和具体培训兴趣将学生分配到生物或化学轨道。被提名者将由两个特定轨道的小组委员会进行评估，然后向PSTP家长委员会推荐任命，并做出最终决定。选择标准包括：UG和研究生GPA，GRE，研究经验，推荐信，研究生院研究轮换的表现，以及个人面试。学生在研究生院第二年开始时进入PSTP，一般由培训补助金资助两年（第一阶段）。严格的招生政策，课程成绩，资格考试，实验室经验和论文工作都由学员的博士课程和PSTP执行，以保持高水平的质量。在第二阶段（候选人资格和PSTP支持后），学员的进展由他们的导师和额外的PSTP教师通过必要的年度论文委员会会议进行监测，并向PSTP董事提交必要的书面报告。要求每年为16名受训人员提供支助。 公共卫生相关性：药理科学培训计划旨在为有兴趣从事与药理研究相关的生命科学研究职业的学生提供高级培训。重点放在基本的药理学原理和获得相关的基础科学，如药物化学的广泛知识。为这些未来的研究人员提供的培训将使他们能够致力于与药物治疗相关的医学和人类健康的进步。

DESCRIPTION (provided by applicant): The University of Michigan, Pharmacological Sciences and Bio-related Chemistry Training Program (PSTP) provides pre-doctoral students with a strong foundation in basic pharmacological principles and a broad knowledge of other bio-related basic science disciplines (e.g., medicinal chemistry). All students will complete a core curriculum consisting of courses in pharmacology, medicinal chemistry, physiology, and biostatistics, with other elective courses designed to fit the programmatic needs of individual students. Students may follow one of two general tracks with emphasis on biological or chemical research. Areas of research concentration within the program include cardiovascular/renal pharmacology, neuropharmacology, xenobiotic metabolism, growth and metabolic regulation, receptor structure and function, synthesis and pharmacology of therapeutic and diagnostic agents, antibiotic discovery, enzymology, transport mechanisms, drug absorption, drug delivery, and pharmacokinetics. Students obtain laboratory experience in several types of pharmacological research and learn how to design experiments, evaluate experimental data, and use appropriate statistical methods. The training program includes graduate-level courses; training in the responsible conduct of research; seminar programs; a qualifying examination; career and professional development activities (new to this submission); required research presentations at an Annual Symposium; supervised laboratory investigation leading to the student's doctoral dissertation and a final oral examination during which the trainee defends his/her dissertation before their dissertation committee. Highly-qualified students, with an interest in obtaining advanced training in the pharmacological sciences that would not normally be available to them in their PhD programs, are nominated by their PhD program to the PSTP. Their faculty mentors must be members of the PSTP. Starting with the 2010-11 cohort, all students nominated to the PSTP will be reviewed by a pre-selection committee, which will assign the students to either the Biological or Chemical Track based on their research and specific training interests. Nominees will then be evaluated by the two track-specific sub-committees, which then recommend appointment to the PSTP Parent Committee which makes the final decisions. Selection criteria include: UG and graduate GPAs, GREs, research experience, letters of recommendation, performance in research rotations in graduate school, and personal interviews. Students enter the PSTP at the beginning of their second year of graduate school and generally are financially supported by the training grant for two years (Phase I). Rigorous policies of admissions, course grades, qualifying exams, laboratory experiences, and thesis work are enforced by both the trainees' PhD programs and the PSTP to maintain a high level of quality. In Phase II (after candidacy and PSTP support), the trainee's progress is monitored by their mentor and by additional PSTP faculty via a requisite annual dissertation committee meeting, with requisite written reports to the PSTP Directors. Support is requested for 16 trainees per year. PUBLIC HEALTH RELEVANCE: The Pharmacological Sciences Training Program is designed to provide advanced training to students interested in pursuing research careers in the life sciences related to pharmacological research. An emphasis is placed on basic pharmacological principles and acquiring broad knowledge of related basic sciences like medicinal chemistry. The training provided to these future researchers will enable them to work on advances in medicine and human health related to drug therapy.