MT INBRE BIOINFORMATICS CORE

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 由Michael富兰克林和Jean Starkey博士指导，并由信息学协调员Kate McInnerney协助，MT INBRE生物信息学和基因组学核心为研究核心的研究人员以及网络和其他州的教师和学生提供服务（阿拉斯加、怀俄明州、威斯康星州、佛罗里达和密苏里州）在数据收集、管理和分析方面的专业知识，除了在蛋白质组学、基因组学、计算生物学方面的专业知识，数据库设计与管理。 研究人员和他们的学生可以使用生物信息学核心设施（包括生物信息学教学和研究设施和系统生物学计算集群），MSU的蛋白质组学和生物质谱仪设施，功能基因组学核心设施，环境化学实验室和蒙大拿大学的电子显微镜设施。 生物信息学和基因组学核心为蒙大拿州的研究人员提供指导和培训机会，包括生物信息学，数据收集，管理和分析的在线课程，生物信息学常用工具和技术的培训，以及学生和教师的研讨会。由核心贡献的资源和专业知识是不可或缺的研究人员和他们的学生，并促进生物信息学分析纳入研究项目。 除了富兰克林博士、斯塔基博士和麦金纳尼女士外，生物信息学核心人员还包括高级生物信息学家奥雷利安·马祖里博士、系统管理员加里·奥瑟、蛋白质组学分析员乔伊斯·布鲁尔（研究生）和功能基因组学核心设施研究生乔安娜·格雷斯。 在INBRE I成功的基础上，生物信息学和基因组学核心侧重于通过持续发展共享设施，研究合作和指导，工作组和培训机会来加强国家的生物医学和生物信息学基础设施。 核心有四个具体目标：1）维护和支持生物信息学教学和研究实验室和系统生物学计算集群，2）提供基础教程，研讨会和课程，使用户能够利用生物信息学工具，并使学生接触不断扩大的生物信息学领域，3）提供一对一的技术支持和指导生物信息学相关研究，4）与校园共享资源设施、蒙大拿州INBRE和COBRE项目负责人、区域INBRE生物信息学核心和其他相关团体合作，以高效和非冗余的方式提供服务。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Directed by Drs. Michael Franklin and Jean Starkey and assisted by Informatics Coordinator Kate McInnerney, the MT INBRE Bioinformatics and Genomics Core provides investigators in the Research Core as well as faculty and students across the network and other states (Alaska, Wyoming, Wisconsin, Florida and Missouri) expertise in data collection, management, and analysis, in addition to expertise in proteomics, genomics, computational biology, and database design and management. Investigators and their students have access to and technical support for the Bioinformatics Core Facility (which includes the Bioinformatics Teaching and Research Facility and Systems Biology Computational Cluster), MSU's Proteomics and Biological Mass Spectrometer Facility, the Functional Genomics Core Facility, Environmental Chemistry Lab, and the University of Montana's Electron Microscopy Facility. The Bioinformatics and Genomics Core provides mentoring and training opportunities to Montana's researchers, including online courses in bioinformatics, data collection, management, and analysis, training in the tools and techniques commonly used in bioinformatics, and workshops for students and faculty. The resources and expertise contributed by the Core are integral to investigators and their students and facilitate the incorporation of bioinformatics analyses into research projects. Bioinformatics Core staff include, in addition to Drs. Franklin and Starkey and Ms. McInnerney, Dr. Aurelien Mazurie, Senior Bioinformatician; Gary Orser, Systems Administration; Joyce Brewer, Proteomics Analysis (graduate student); and Joanna Gress, graduate student in the Functional Genomics Core Facility. Building on successes in INBRE I, the Bioinformatics and Genomics Core focuses on strengthening the state's biomedical and bioinformatics infrastructure through continued development of shared facilities, research collaborations and mentoring, working groups, and training opportunities. The Core has 4 specific goals: 1) maintain and support the Bioinformatics Teaching and Research Lab and Systems Biology Computational Cluster, 2) offer foundational tutorials, workshops and courses that enable users to take advantage of bioinformatics tools and expose students to the expanding field of bioinformatics, 3) provide one-on-one technical support and mentoring of bioinformatics related research, and 4) collaborate with campus-based shared resource facilities, Montana INBRE and COBRE Project Leaders, regional INBRE bioinformatics cores, and other relevant groups to deliver services in an efficient and non-redundant manner.