The Role of Altered Permeability in Bladder Diseases

我们假设，有一种统一的机制与急性或慢性因素有关，这些因素损害了 通常保护膀胱的不渗透屏障。因此，我们提出，增加的渗透率 膀胱是许多良性膀胱疾病的根本原因。(1)在膀胱再生方面， 愈合和纤维化是由于新生器官对尿液的渗透性而有利于纤维化的，我们将 用动物模型研究降低再生膀胱的通透性如何促进愈合。 (2)在IC/PBS中，由渗漏引起的感觉神经去极化和结构改变是其基础。 病理学。共病研究表明，肠道和膀胱之间存在着相互作用的关系。 其中一种的变化会导致另一种的渗透性变化，而动物研究也证明了这种相互作用 将揭示与临床人群相关的机制。渗透性增加可能是OAB的一个因素 井。因此，我们计划进行一项临床研究，以确定IC/PBS和CPP通透性增加的作用 和LUTS作为衰老的函数。

We hypothesize that there is a unifying mechanism associated with acute or chronic factors that damage the impermeability barrier that normally protects the bladder. Thus, we propose that increased permeability of the bladder is a root cause of many benign bladder diseases. (1) In bladder regeneration, the race between healing and fibrosis is tipped in favor of fibrosis by permeability of the nascent organ to urine, and we will investigate with animal models how decreasing permeability of the regenerating bladder facilitates healing. (2) In IC/PBS, depolarization of sensory nerves and structural changes induced by leakiness underlie that pathology. Comorbidity studies suggest that a reciprocal relationship exists between bowel and bladder such that changes in one induces permeability changes in the other, and animal studies of this reciprocity will reveal mechanisms relevant to clinical populations. Increased permeability may be a factor in OAB as well. We, therefore, plan a clinical study to determine the role of increased permeability in IC/PBS and CPP and LUTS as a function of aging.