High School Student NeuroResearch Program (HSNRP)

描述（由申请人提供）：亚利桑那大学（UA）高中生神经研究计划（HSNRP）将引进、培训和培养越来越多的有才华的亚利桑那高中学生，包括代表性不足的少数民族，从事正常和异常神经系统、神经疾病和中风的基础、转化和临床研究，并鼓励追求先进的研究经验和健康/科学相关的职业。我们将利用强大的基础设施，有效的招聘策略，高水平的学生/教师导师参与，团队精神，以及我们长期以来联邦资助的多学科/多专业弱势高中生和医学院学生暑期研究项目的优秀实习生生产力，为这个新的专业神经研究（NR）项目开发培训模式。未来5年，每年将有12至14名全日制暑期高中学员获得神经研究（NR）经验的密切指导；2-4名将被重新任命为高级自然科学的本科生。这些将被整合到一个创新的研究型医学无知暑期研究所（SIMI）中，交织生物医学已知和未知（“我们知道我们不知道的，不知道我们不知道的，以及认为我们知道但不知道的”），具有特色的自然科学主题，并通过全年定期的丰富活动来维持。SIMI强调“翻译翻译”，包括高中水平的病理生物学简介、专题研讨会、实验室/领导/多媒体技能讲习班、临床相关性、社会网络和职业建议。一个独特的虚拟临床研究中心/问卷调查中心形成了培训和国家/国际网络的核心。在HSNRP领导团队和咨询委员会的监督下，在基础和临床部门以及专业卓越中心内，高中生的研究将涵盖跨领域主题，以及体内、体外、原位、计算机和神经生物学/疾病的建模方法，包括帕金森、阿尔茨海默病、尼曼-皮克C病、ALS、癫痫、艾滋病毒脑病、头部创伤、脑积水、肌肉萎缩症、疼痛/成瘾药理学。分子精神病学、认知学、脑发育、衰老、智力低下、血脑屏障/神经保护、神经影像学、神经基因组学/蛋白质组学、神经工程、脑深部刺激、脑癌、脑血管疾病、中风、康复。基于我们约25年的跟踪记录，并建立了对474名SIMI培训的亚利桑那州弱势学生的广泛访问，这些学生反映了迄今为止许多基础/临床神经研究的高中生，我们期望HSNRP：培养一个不断扩大的多样化研究人员、医生和其他卫生专业人员的网络；为NeuroResearch的产品线和企业做出贡献；并通过社区参与提高“神经健康”素养。正在进行的短期和长期评价，包括调查、数据库登记和职业组合将证明培训模式的效力并促进联网。

DESCRIPTION (provided by applicant): The University of Arizona (UA) High School Student NeuroResearch Program (HSNRP) will introduce, train, and nurture a growing cadre of diverse talented Arizona high school students including under-represented minorities in basic, translational, and clinical research on the normal and abnormal nervous system, neurological disorders, and stroke as well as encourage pursuit of advanced research experiences and health/ science-related careers. We will leverage the strong infrastructure, effective recruitment strategies, high level of student/faculty mentor participation, esprit-de-corps, and outstanding trainee productivity of our long-standing federally funded multidisciplinary/multispecialty disadvantaged high school student and medical student summer research programs to develop the training model for this new specialized NeuroResearch (NR) program. Twelve to 14 full-time summer high school trainees annually for the next 5 years will be offered an expanding menu of closely mentored NeuroResearch(NR) experiences; 2-4 will be reappointed as under- graduates for advanced NR. These will be integrated into an innovative inquiry-based Summer Institute on Medical Ignorance (SIMI) interweaving biomedical Knowns and Unknowns ("what we know we don't know, don't know we don't know, and think we know but don't") with featured NR topics and sustained by periodic enrichment activities year round. SIMI emphasizes "translating translation" and includes a high school level brief Introduction to Pathobiology, topical seminars, laboratory/leadership/multimedia skill workshops, clinical correlations, social networking, and career advising. A unique Virtual Clinical Research Center/Questionarium forms a centerpiece for training and national/international networking. Within basic and clinical departments and specialized Centers of Excellence and overseen by an energetic HSNRP Leadership Team and Advisory Committee, high school student research will encompass cross-cutting themes and in vivo, in vitro, in situ, in silico, and modeling approaches to neurobiology/disorders including Parkinson, Alzheimer, Niemann-Pick C diseases, ALS, epilepsy, HIV encephalopathy, head trauma, hydrocephalus, muscular dystrophy, pain/ addiction pharmacology, molecular psychiatry, cognition, brain development, senescence, mental retardation, blood-brain barrier/neuroprotection, neuroimaging, neuro-genomics/proteomics, neuroengineering, deep brain stimulation, brain cancer, cerebrovascular disease, stroke, and rehabilitation. Based on our ~25-year track record and established access to large diverse pools of disadvantaged Arizona students reflected in 474 SIMI- trained high school students followed to date with many in basic/clinical NeuroResearch, we expect HSNRP to: cultivate an expanding network of diverse researchers, physicians and other health professionals; contribute to the NeuroResearch pipeline and enterprise; and improve "neurohealth" literacy through community engagement. Ongoing short-term and long-term evaluation including surveys, database registry and career portfolios will document efficacy of the training model and promote networking.