Biomechanics of the False Vocal Folds

摘要 这项研究的长期目标是建立生物力学、声学和 空气动力学与功能性嗓音障碍的相关性 脑室或假声带(FVF)。这一目标必然包括 开发和使用有效的发声模型，并量化发声 生物力学、空气动力学和声学因素控制喉部功能和 音质。此应用程序的目标是建立对 假声带振荡的生物力学、空气动力学和声学。这一目标 将通过实验和计算相结合的方法来满足。那里 这个项目有四个具体目标。这些目标是：1)建立有害的 不规则FVF振荡的影响，2)生物力学和组织学鉴定 FVF组织的特性，3)识别空气动力学和声学效应 与FVF定位相关，以及4)量化FVF的生物力学效应 关于喉咙的摆动。 这项建议具有很强的临床意义，因为它解决了一些主要问题 在发声障碍中，如脑室麻痹。成功地完成这项工作 该项目将加深我们对脑室发声的形式和功能的了解 折叠，无论是关于它们对正常声音产生的影响，还是关于它们的 导致嗓音改变或紊乱。FVF的详细而系统的研究 解剖学、生物力学和神经肌肉控制有望提供 对声音产生机制及其控制的重要见解，以及 我们治疗病态嗓音的方法有所改进。在这份提案中，我们 打算回答有关以下方面的研究问题：振动特性(Fo范围， 运动幅度、运动对称性、模式)、声学特性(依赖 关于内收、延长、A-P压缩)、空气动力学(压力、流动、流动 阻力，PTP)和组织特性(弹性模数、粘度、肌肉 架构)。

Abstract The long-range objective of this research is to establish biomechanical, acoustic, and aerodynamic correlates of functional voice disorders that are implicated by the presence of the ventricular or false vocal folds (FVF). This goal, by necessity, must include the development and use of effective models of phonation, and quantification of the biomechanical, aerodynamic, and acoustic factors that control laryngeal function and voice quality. The objective of this application is to establish a firm understanding of the biomechanics, aerodynamics, and acoustics of false vocal fold oscillation. This objective will be met through a combination of experimental and computational methods. There are four specific aims in this project. These aims are: 1) To establish the detrimental effects of irregular FVF oscillations, 2) To identify the biomechanical and histological characteristics of FVF tissue, 3) To identify the aerodynamic and acoustic effects associated with FVF positioning, and 4) To quantify the biomechanical effects of the FVF on laryngeal oscillations. This proposal has strong clinical relevance as it addresses some of the major concerns in voice disorders such as ventricular disphonia. The successful completion of this project will enhance our understanding of the form and function of the ventricular vocal folds, both with respect to their influence in normal sound production and their contribution to altered or disordered voice. Detailed and systematic study of FVF anatomy, biomechanics, and neuromuscular control can be expected to provide important insights into the mechanism of sound production and its control, and improvements in our approaches to treating the pathological voice. In this proposal we intend to answer research questions regarding: vibratory characteristics (Fo range, amplitude of motion, symmetry of motion, modes), acoustic characteristics (dependence on adduction, lengthening, A-P compression), aerodynamics (pressure, flow, flow resistance, PTP), and tissue characteristics (elastic modulus, viscosity, muscle architecture).