Design, construction, and evaluation of implants for vocal fold alteration and re

项目总结 拟议研究的广泛目标是应用设计、动态测试和材料测试方法 更好地了解现有的和新的声带植入物的影响以及 声带中性化、部分或全部固有层重建的机械性假体 自然喉组织的特性和动态响应，以及最终的声音质量。据推测， 所提出的方法的系统应用最终将有助于创造植入物和 具有机械性能的假体，代表坚固耐用的天然组织。工作量很大 已经完成了声带植入物和假体用于声带病理外科修复的研究 累及固有层，如疤痕、声沟和萎缩，临床上仍具有挑战性。 喉科和音响外科的问题。使用的生物材料包括特定类型的脂肪、胶原蛋白、 透明质酸、筋膜和各种合成材料，如硅胶、Gore-Tex或羟基磷灰石。 以前的工作是在没有详细了解材料的机械性能和响应的情况下完成的 使用的合成材料或生物材料。这可能导致了次优的振荡函数，并降低了 音质。本研究旨在开发和评估合成模型、植入物和 具有一套机械性能的假体，与人类声带组织的测量数据非常匹配。 将完善喉的合成模型，并用于基础研究，以及为新的 植入物。为了获得动态的全场应变数据，将开发数字图像相关方法 以及应力估计，这将有助于量化假体和植入物对机械反应的影响。 声带共振频率与张力、空气流速和假体设计的关系 量化的。所选择的基质蛋白对固有层粘弹性的影响将是 为了更好地测量下组织对外来物质的生物反应的后果 包裹体。植入物和天然组织之间的结合问题将使用原子力进行检查。 显微镜。

PROJECT SUMMARY The broad objective of the proposed studies is to apply design, dynamic testing, and material testing methods from Mechanical Engineering to better understand the impact of existing and new vocal fold implants and prostheses for vocal fold medialization, partial or total lamina propria reconstruction on the mechanical properties and dynamic response of native laryngeal tissue and, ultimately, voice quality. It is postulated that the systematic application of the proposed methods will eventually help the creation of implants and prostheses with mechanical behavior representative of native tissue that are robust and durable. Much work has been done on the use of vocal fold implants and prostheses for the surgical repair of vocal pathologies involving the lamina propria, such as scarring, sulcus vocalis, and atrophy, which remain challenging clinical problems in laryngology and phonosurgery. Biomaterials used have included specific types of fat, collagen, hyaluronic acid, fascia, and a variety of synthetic materials such as silicone, Gore-Tex, or hydroxyapatite. Previous work has been done without a detailed knowledge of the mechanical properties and response of the synthetic or biological materials used. This may have resulted in sub-optimal oscillatory function, and reduced voice quality. The present study aims at developing and evaluating synthetic models, implants, and prostheses with a set of mechanical properties that closely match measured data for human vocal fold tissue. Synthetic models of the larynx will be perfected and used for fundamental studies, as well as test beds for new implants. Digital image correlation methods will be developed in order to obtain dynamic, full field strain data and stress estimates that will help quantify the influence of prosthesis and implants on mechanical response. The dependence of the vocal folds resonance frequencies on tension, air flow rate, and implant design will be quantified. The influence of selected matrix proteins on the viscoelastic properties of the lamina propria will be measured in order to better under the consequences of the biological response of the tissue to foreign inclusions. The issues of bonding between implants and native tissue will be examined using atomic force microscopy.