PA-06-555 Senior Scientist Research and Mentorship Award (K05)

描述（由申请人提供）：这种竞争性的更新反映了我的长期研究和职业目标，以研究成瘾治疗，产生信息，改善结果，减少成瘾对他人的负担，扩大国际成瘾研究，并指导年轻的研究人员成瘾研究职业。为此，我一直是PI或Co-l研究抗抑郁药物治疗，丙氧芬维持，美沙酮维持及其对艾滋病毒风险和感染的影响，LAAM，丁丙诺啡，心理治疗，艾滋病毒疫苗，艾滋病毒快速检测，巴西和俄罗斯的艾滋病毒和药物使用，纳洛酮用于治疗海洛因成瘾和降低俄罗斯和美国的艾滋病毒风险，美沙酮患者谁不停止阿片类药物的使用，激励措施，激励增强，和其他作为P.I.临床试验网络（CTN）的特拉华州山谷节点。我是NIDA研究部门的成员，FDA药物滥用咨询委员会，DSM-IV药物滥用工作组，CPDD董事会和美国精神病学协会成瘾精神病学委员会。我指导年轻的研究人员，为许多期刊撰写评论论文，是两个的副编辑，监督居民，参与医学生教学，并共同指导费城VA卓越中心的成瘾部分，直到2004年从VA退休。未来5年的研究活动包括发表青少年/年轻成人阿片类药物依赖者的丁丙诺啡研究结果，这是先前K奖的重点，完成我们小组目前参与的CTN研究，开发关于在初级保健中整合药物滥用干预措施的影响的CTN研究，完成在俄罗斯圣彼得堡彼得堡的纳洛酮植入研究和在基辅的美沙酮研究，提交R 01研究纳洛酮植入剂与口服纳洛酮对彼得堡艾滋病毒+海洛因成瘾者坚持抗逆转录病毒药物治疗的影响，在格鲁吉亚共和国开展每周三次Suboxone治疗Subutex成瘾的研究，以及在巴西开展Concerta降低患有ADHD和大麻滥用或依赖的青少年艾滋病毒风险的研究，帮助制定在俄罗斯将成瘾和艾滋病毒治疗相结合的指导方针，就初级保健中美沙酮维持治疗的研究和植入丁丙诺啡的研究提供咨询，并制定一项研究，以评估向出狱的阿片类药物依赖者提供治疗的影响。目前的学员是两名VA/NIDA研究员，一名来自马来西亚的INVEST研究员和一名来自第比利斯的学员。教育活动包括监督宾夕法尼亚州居民，领导宾夕法尼亚州和弗吉尼亚州的病例会议，参加医学生的成瘾课程，并与国际合作者合作研究主题，包括研究设计，实施，质量保证程序，人类受试者保护，撰写论文和促进良好临床实践。

DESCRIPTION (provided by applicant): This competing renewal reflects my long-term research and career objectives to study addiction treatment, generate information that improves outcome and reduces the burden of addiction on others, expand international addiction research, and mentor young investigators for addiction research careers. To this end, I have been PI or a Co-l on studies on antidepressant pharmacotherapy, propoxyphene maintenance, methadone maintenance and its impact on HIV risk and infection, LAAM, buprenorphine, psychotherapy, a HIV vaccine, a rapid HIV test, HIV and drug use in Brazil and Russia, naltrexone for treating heroin addiction and reducing HIV risk in Russia and the U.S., methadone patients who do not stop opioid use, motivational incentives, motivational enhancement, and others as P.I. of the Delaware Valley Node of the Clinical Trials Network (CTN). I have been a member of NIDA study sections, the FDA Drug Abuse Advisory Committee, the DSM-IV Substance Abuse Work Group, CPDD Board of Directors, and the Board of Addiction Psychiatry for the American Psychiatric Association. I mentor young investigators, review papers for many journals, am associate editor of two, supervise residents, participate in medical student teaching, and co-directed the addictions component of the Philadelphia VA Center of Excellence until retiring from the VA in 2004. Research activities for the next 5 years include publishing results of the buprenorphine study of adolescent/young adult opioid dependent individuals that was a focus of the prior K award, finishing CTN studies in which our group is currently participating, developing CTN studies on the impact of integrating substance abuse interventions in primary care, completing a naltrexone implant study in St. Petersburg Russia and a methadone study Kiev, submitting a R01 to study the impact of naltrexone implant vs. oral naltrexone on adherence to antiretroviral medication in HIV+ heroin addicts in St. Petersburg, developing a study of thrice weekly Suboxone for Subutex addiction in the Republic of Georgia, and a study of Concerta for reducing HIV risk in adolescents with ADHD and marijuana abuse or dependence in Brazil, helping develop guidelines for integrating addiction and HIV treatment in Russia, consulting on a study of methadone maintenance in primary care and a study of implant buprenorphine, and developing a study to assess the impact of offering treatment to opioid dependent persons being released from prison. Current mentees are two VA/NIDA fellows, an INVEST fellow from Malaysia, and a mentee from Tbilisi. Educational activities include supervising a Penn resident, leading case conferences at Penn and the VA, participating in an addiction course for medical students, and working with international collaborators on research topics including study design, implementation, procedures for quality assurance, human subjects protection, writing papers, and facilitating Good Clinical Practice.