Core E:Training Core

本申请建议BU SRP培训核心将继续提供跨学科培训 实验室科学、生物信息学和计算生物学，同时还扩大培训核心以采取行动 作为所有在BU工作的研究生和博士后研究员的共同参考点 SRP计划(包括由其他BU SRP项目、其他相关培训计划、 并直接由培训中心提供)。培训核心每年将直接支持两名学生 生物信息学技术应用于实验室科学，重点分析高 吞吐量、全基因组数据集和分子建模。这一重点是对战略 这些方法对于未来生物学的重要性，在传统的生物学中相对缺乏接触 实验室培训计划，以及申请机构的独特资源。这是一个主要的因素 计划主题，发育中的有机体对低水平异生暴露的敏感性 多种多样的途径，非常适合作为这种跨学科培训的背景。在提名后由 项目绩效评估在第一年的学习结束时，两名学生将被一个指导委员会挑选出来 由计划主任、培训核心主任和另外两个BUSRP绩效指标组成，视情况而定 他们对BUSRP内的一个实验室的承诺。这些学生将获得适当的核心 课程包括生物信息学、生殖与发育、环境健康和毒理学 他们的训练计划。此外，我们专注于沟通技能，而不仅仅是在科学界 而是向更广泛的社区传播科学知识，弥合“沟通鸿沟” 在板凳科学和实验室科学以及广大公众之间。重要的是，培训核心将面向 由BU SRP项目或培训核心支持的研究生和博士后研究员 NIEHS SRP、EPA以及州环境和卫生机构的任务、活动和需求；以及 从而发展出一种共同的使命感和同行网络，因为他们致力于推动科学 需要为解决与以下方面相关的复杂健康和环境问题提供坚实的基础 这个国家的危险废弃场。

This application proposes that the BU SRP Training Core will continue to provide interdisciplinary training in laboratory science, bioinformatics and computational biology, while also expanding the Training Core to act as a common reference point for all graduate students and post-doctoral fellows who work within the BU SRP program (including those who are supported by other BU SRP projects, other related training programs, and directly by the Training Core). The Training Core will directly support two students a year in bioinformatics techniques applied to the laboratory sciences, with an emphasis on analysis of high throughput, genome-wide data sets and on molecular modeling. This focus responds to the strategic importance of these methods for the biology of the future, the relative lack of exposure to them in traditional laboratory training programs, and the unique resources ofthe applicant institution. A major element ofthe program theme, the susceptibility ofthe developing organism to low-level xenobiotic exposures through a variety of pathways, is ideally suited to be the context for this cross discipline training. After nomination by project PIs at the end of their first year of study, two students will be selected by a Steering Committee consisting ofthe Program Director, the Training Core Director, and two additional BUSRP PIs, contingent on their commitment to one of the laboratories within the BUSRP. These students will receive appropriate core courses covering bioinformatics, reproduction and development, environmental health, and toxicology during their training program. In addition, we focus on communication skills, not only within the scientific community but to disseminate scientific knowledge to the broader community and to close the "communication gap" between bench and laboratory science and the public at large. Importantly, the Training Core will orient graduate students and post-doctoral fellows supported by BU SRP projects or the Training Core to the mission, activities and needs of the NIEHS SRP, EPA and state environmental and health agencies; and thereby develop a sense of shared mission and peer network as they work towards advancing the science needed to provide a firm foundation for solving the complex health and environmental issues associated with the nation's hazardous waste sites.