Core B: Facility/Service Cores

组织采购核心通过整合 采购符合基础科学研究项目需要的临床组织。组织的目标是 采购的核心是优化调查人员使用自发流产的胎儿组织的能力 了解在发育过程中因环境暴露而改变的潜在表观遗传途径 会导致儿童和成人疾病。这一核心的目标将通过以下具体目标实现： ·具体目标1：便利查明、列入和快速采购自发的 流产(流产)将被纳入形成中心研究进行评估 协议。 具体目标2：评估、获取和处理选定的胎儿组织，以确保成功使用 在提议的研究项目中的组织。这些组织包括：胎肺、肝和 前列腺组织。 具体目标3：为包括儿科、新生儿在内的临床研究员提供机会。 病理学和母胎医学研究员，从事与形成相关的研究 中心。 开发组织采购核心是为了便于确定适当的标本， 同意经历过自然流产的妇女，从 流产的胎儿，及时处理组织以优化科学应用，并开发 用于短期利用并最终用于长期组织存储的系统。这一核心的成功依赖于 密集的监测、社区外展和教育以及广泛的参与和 与临床团队进行协调。通过组织采购核心提供的临床界面是 形成中心的基本要素，提供整合个人和公共卫生的专业知识 与研究计划的相关性。

The Tissue Procurement Core supports the development of the Formative Center by integrating the procurement of clinical tissues with the needs of the basic science research projects. The goal of the Tissue Procurement Core is to optimize the ability for investigators to use spontaneously aborted fetal tissue to understand the underlying epigenetic pathways altered by environmental exposures during development that lead to childhood and adult diseases. The goal of this core will be met through the following specific aims: ¿ Specific Aim 1: Facilitate the identification, inclusion and rapid procurement of spontaneous abortions (miscarriages) to be evaluated for enrollment in the Formative Center research protocol. ¿ Specific Aim 2: Evaluate, procure and process selected fetal tissues to ensure successful use of the tissues in the proposed research projects. These tissues include: fetal lung, liver and prostate tissue. ¿ Specific Aim 3: Provide opportunities for clinical fellows, including Pediatric, Neonatology. Pathology and Maternal Fetal Medicine fellows, to engage in research related to the Formative Center. The Tissue Procurement Core has been developed to facilitate identifying appropriate specimens, consenting women who have experienced a spontaneous abortion, acquiring the essential tissues from the aborted fetus, processing the tissues in a timely fashion to optimize scientific applications, and developing systems for short-term utilization and eventually, for long-term tissue storage. Success of this core relies on intensive surveillance, community outreach and education as well as extensive engagement and coordination with the clinical team. The clinical interface provided through the Tissue Procurement core is a fundamental element of the Formative Center, providing expertise to integrate individual and public health relevance to the research program.