FASEB SRC on Virus Structure and Assembly

描述（由申请人提供）：感染性病毒在细胞内的组装是一个复杂的过程，需要病毒和宿主来源的许多大分子的时间和协调活性。在分子水平上理解这些相互作用对于开发有效的抗病毒疗法以及利用这些相对简单的系统作为校正基因递送载体和纳米材料至关重要。对这些重要过程的全面检查最好通过多学科方法来完成，包括遗传学，分子生物学，细胞生物学以及结构，生物化学和生物物理方法。FASEB病毒结构和组装夏季研究会议是这些不同学科的研究人员聚集和讨论该领域前沿成果和重大突破的重要会议。事实上，许多新的抗病毒疗法是基础科学研究的直接结果，这一直是过去FASEB会议的重点。这份申请要求提供资金，以支持这一享有盛誉的重要会议。 公共卫生相关性：了解感染性病毒如何进入宿主细胞并随后在宿主细胞中组装对于开发新的抗病毒疗法和开发用于生物技术应用的病毒系统至关重要。该申请寻求对FASEB病毒结构和组装夏季研究会议的支持，该会议是一个重要的科学会议，旨在解决病毒进入和组装中的各种问题。

DESCRIPTION (provided by applicant): The assembly of an infectious virus within the cell is a complex process that requires the temporal and coordinated activities of numerous macromolecules of both viral and host origin. Understanding these interactions at the molecular level is essential to the development of effective anti-viral therapeutics and to harnessing these relatively simple systems for use as corrective gene delivery vectors and as nanomaterials. A comprehensive examination of these important processes is best accomplished by a multi-disciplinary approach that includes genetics, molecular biology, cell biology, and structural, biochemical and biophysical approaches. The FASEB Summer Research Conference on Virus Structure and Assembly has served as a key meeting for researchers in these diverse disciplines to gather and discuss cutting edge results and major breakthroughs in the field. Indeed, many new anti-viral therapies are the direct result of basic scientific investigations, which has been the emphasis of past FASEB conferences. This application requests funds to support this prestigious and important meeting. PUBLIC HEALTH RELEVANCE: Understanding how an infectious virus enters into and subsequently assembles in the host cell is essential to developing new anti-viral therapeutics and to developing viral systems for biotechnology applications. This application seeks support for the FASEB Summer Research Conference on Virus Structure and Assembly, a key scientific meeting that addresses diverse issues in virus entry and assembly.