ASBMR Topical Meeting on Bone and Skeletal Muscle Interactions

描述（由申请人提供）：肌肉骨骼疾病的年度医疗保健费用为数十亿美元。每年发生的所有伤害中有一半以上是肌肉骨骼系统伤害，导致工作和上学时间的重大损失。儿童时期的肌肉骨骼疾病可能是毁灭性的，随着年龄的增长，肌肉减少症和骨质疏松症的负担不断增加。肌肉减少症，肌肉萎缩，导致平衡差，步行速度降低，福尔斯和骨折，可以被认为是骨质疏松症的肌肉等价物。虽然肌肉和骨骼对运动有反应是众所周知的，但我们对这两种组织之间的细胞和分子相互作用知之甚少。因此，我们建议召开一次会议，召集国内外领先的肌肉和骨骼研究人员交流思想，并开展新的合作。这次会议将为在肌肉和骨骼相互作用这一重要领域迅速和公开地交流思想和研究成果创造一个场所。我们会议的近期目标是确定关键的 研究主题，将导致肌肉和骨骼研究人员之间的合作赠款申请，然后在出版物和演示文稿等场所传播本次会议的结果。本次会议将讨论的具体目标包括：了解肌肉和骨骼在发育和生长过程中的密切联系，以及营养和体育活动如何影响总体健康，剖析衰老在 肌肉减少症和骨质疏松症之间的关联，以鉴定负责肌肉和骨之间的紧密关联的分子和细胞机制，以定义肌肉和骨中有缺陷的机械传导，以确定肌肉是否与骨不依赖于机械负荷而连通，以鉴定预防、治疗和逆转或再生肌肉和骨损失的关节方法，并评估建立一个结合肌肉和骨骼生理学的联合研究领域的可行性。最终目标是更好地了解这两种组织如何在健康和疾病中整合和相互作用。我们的目标和希望是，这次会议将引发新的治疗策略，以加强和保持肌肉骨骼健康。 公共卫生相关性：从童年到老年，骨骼和肌肉是紧密相连的。任一组织的疾病或损伤都会影响另一组织。尽管骨骼的肌肉负荷在这种相互作用中起着重要作用，但对潜在的细胞和分子机制知之甚少。因此，本次会议建议将领先的肌肉和骨骼研究人员聚集在一起，以确定关键的研究领域，这将导致合作，以解决肌肉骨骼疾病。

DESCRIPTION (provided by applicant): Annual health care costs for musculoskeletal disease are in the billions. More than half of all injuries occurring each year are to the musculoskeletal system resulting in significant loss of work and school days. Musculoskeletal disease in childhood can be devastating and the burden of sarcopenia and osteoporosis with age continues to increase. Sarcopenia, muscle wasting, results in poor balance, reduced walking speed, falls, and fractures and can be thought of as the muscular equivalent of osteoporosis. Although it is well recognized that muscle and bones are responsive to exercise, we know little regarding cellular and molecular interactions between these two tissues. Therefore, we are proposing a conference to draw together leading muscle and bone researchers nationally and internationally to exchange ideas and to develop new collaborations. This conference would create a venue for the rapid and open exchange of ideas and research results in this important field of muscle and bone interactions. The immediate goal of our conference is to identify critical research themes that would lead to collaborative grant applications between muscle and bone researchers followed by dissemination of findings from this meeting in venues such as publications and presentations. Specific aims to be addressed at this meeting include: to understand the close association between muscle and bone during development and growth and how nutrition and physical activity affects general health, to dissect the role of aging in the association between sarcopenia and osteoporosis, to identify molecular and cellular mechanisms responsible for the close association between muscle and bone, to define defective mechanotransduction in both muscle and bone, to determine if muscle communicates with bone independent of mechanical loading, to identify joint approaches to prevent, treat, and reverse or regenerate muscle and bone loss, and to assess the feasibility of establishing a combined research field that integrates both muscle and bone physiology. The ultimate goal is to generate a better understanding of how these two tissues integrate and crosstalk in both health and disease. The goal and hope is that this meeting will trigger new therapeutic strategies to enhance and maintain musculoskeletal health. PUBLIC HEALTH RELEVANCE: Throughout life, from childhood to old age, bone and muscle are tightly and intimately connected. Disease or injury in either tissue affects the other. Althoug muscle loading of bone clearly plays a role in this interaction, little is known about potential cellular and molecular mechanisms. Therefore this conference is proposed to bring together leading muscle and bone researchers to identify critical research areas that would lead to collaborations to address musculoskeletal disease.