Steroid Hormone Signaling in Genetically Obese Drosophila

描述（由申请人提供）：遗传性肥胖果蝇是通过选择饥饿抗性而产生的。本计画将探讨导致果蝇累积过量脂质的荷尔蒙机制。基因组学方法将用于确定脂质储存的遗传基础。 公共卫生相关性：这项研究使用遗传肥胖果蝇作为模型，以了解导致人类肥胖的遗传因素。目标是确定导致细胞和动物积累脂肪的基因和激素途径。

DESCRIPTION (provided by applicant): Genetically obese Drosophila has been developed by selecting for starvation resistance. This project will investigate hormonal mechanisms that cause Drosophila to accumulate excess lipids. Genomic methods will be used to identify the genetic basis for lipid storage. PUBLIC HEALTH RELEVANCE: This study uses genetically obese fruit flies as a model to understand genetic factors contributing to human obesity. The goal is to identify genes and hormonal pathways that cause cells and animals to accumulate fat.