Partnerships for Biomedical Research in Arkansas

这项提案将延续阿肯色州IDEA生物医学研究卓越网络(INBRE)的目标，扩大阿肯色州的生物医学研究能力。在INBRE第一阶段建立的基础设施的基础上，该州的三个研究密集型领先机构-阿肯色大学医学科学、阿肯色大学费耶特维尔和阿肯色大学小石城分校-将提供科学领导。来自六所本科院校的13名研究人员将与他们在领先机构的导师合作，在细胞信号、生长和分化的总主题下进行研究。行政核心将协调阿肯色州INBRE的所有活动，并促进这13名调查人员的研究成果。全州本科生研究人员之间的互动将在INBRE全体教职员工参加的年度会议上得到强调。阿肯色州INBRE将继续致力于为代表不足的群体扩大机会。INBRE将与多样性事务中心和该学院合作，推进NIH新资助的最大化学生多样性倡议(IMSD)计划的目标，以增加在UAMS完成生物医学科学研究生学位的少数族裔学生的数量。INBRE参与者之间的交流将由通过Internet2连接的Access Grid工作室提供便利。生物信息学核心将成为全州范围内的研究和教育资源，为本科教师和学生提供多学科生物医学研究所需的计算工具。该中心还将主办与杰克逊州立大学(密西西比州RCMI)的学生交流活动，以合作进行非裔美国人心血管疾病的长期研究。阿肯色州INBRE还将支持由蛋白质组学、数字显微镜和DNA损伤/毒理学设施组成的科学研究核心。这些将使调查人员能够获得在小型机构难以建立的尖端仪器和技术专长。外展中心将为全州的非INBRE本科教师和学生提供有指导的暑期研究机会。通过进一步加强研究基础设施，特别是本科院校，阿肯色州INBRE将提高学术研究人员竞争联邦资金的能力，增加选择生物医学研究职业的本科生数量，并刺激阿肯色州生物技术产业的增长。

This proposal will continue the goals of the Arkansas IDeA Network for Biomedical Research Excellence (INBRE) to expand biomedical research capacity in Arkansas. Building upon infrastructure developed during the first INBRE phase, three research-intensive, lead institutions in the state¿the University of Arkansas for Medical Sciences; the University of Arkansas, Fayetteville, and the University of Arkansas at Little Rock¿will provide scientific leadership. Thirteen investigators, faculty from six undergraduate institutions, in collaboration with their mentors at the lead institutions, will conduct research under the overall theme of Cellular Signaling, Growth, and Differentiation. The Administrative Core will coordinate all Arkansas INBRE activities and facilitate the research accomplishments of these 13 investigators. The interactions among undergraduate researchers across the state will be highlighted by an annual conference attended by all INBRE faculty and students. The Arkansas INBRE will continue its commitment to expand opportunities for underrepresented groups. The INBRE will partner with the Center for Diversity Affairs and the School in advancing the goals of the newly NIH-funded Initiative for Maximizing Student Diversity (IMSD) Program to increase the numbers of minority students completing graduate degrees in the biomedical sciences at UAMS. Communication among INBRE participants will be facilitated by Access Grid Studios linked through Internet2. The Bioinformatics Core will be a statewide research and educational resource to give undergraduate faculty and students access to the computational tools needed for multidisciplinary biomedical research. This Core will also host a student exchange with Jackson State University (a Mississippi RCMI) to collaborate In a long-term study of cardiovascular disease in African Americans. The Arkansas INBRE will also support a Science Research Core consisting of proteomics, digital microscopy and DNA damage/toxicology facilities. These will provide investigators access to sophisticated instrumentation and technical expertise difficult to establish at a small institution. The Outreach Core will offer mentored summer research opportunities to non-INBRE undergraduate faculty and students throughout the state. Through further enhancement of research infrastructure, particularly at undergraduate Institutions, the Arkansas INBRE will improve the ability of academic researchers to compete for federal funding, increase the number of undergraduate students who choose careers in biomedical research, and stimulate the growth of biotechnical industries in Arkansas.