Effect of tendon damage accumulation on healing and adaptation

描述(申请人提供)：肌腱损伤累积和肌腱撕裂是肌肉骨骼残疾的主要来源，困扰着整个社会。尽管这些问题很重要，但临床医生对治疗建议缺乏科学依据，因为运动可以改善肌腱动态平衡和抗损伤能力的机制，导致疲劳损伤的肌腱愈合不良的机制，以及活动对修复的疾病肌腱愈合的影响尚不清楚。以前的研究已经调查了运动和撕裂的影响，但仅限于健康的肌腱。我们已经建立并广泛表征了疲劳损伤在大鼠体内积累的模型，现在建议研究疲劳损伤的肌腱对运动和/或撕裂的反应。这些研究，使用这种临床相关的肌腱模型，将为新的和改进的治疗策略提供基础。

DESCRIPTION (provided by applicant): Damage accumulation in tendons and tendon tears are a major source of musculoskeletal disability, afflicting the entire spectrum of society. Despite the importance of these problems, clinicians have little scientific basis for treatment recommendations because mechanisms whereby exercise may improve tendon homeostasis and resistance to injury, mechanisms responsible for the poor healing of fatigue damaged tendons, and the effect of activity on the healing of repaired diseased tendons are unknown. Previous studies have investigated the effects of exercise and laceration, but only in healthy tendon. We have developed and extensively characterized an in vivo model of fatigue damage accumulation in the rat patellar tendon, and now propose to study the response of fatigue damaged tendon to exercise and/or laceration. These studies, using this clinically relevant model of diseased tendons, will provide the foundation for novel and improved treatment strategies.