Development of Mult-Spectral Fluorescence Scanning Fiber Endoscope (SFE)

项目概述：将开发一种多光谱扫描纤维内窥镜（SFE），用于对项目2中开发的荧光标记肽板进行成像，这些肽对项目1中确定的扩增和/或过表达的基因靶标具有特定的结合活性。将开发图像处理算法，将单个图像拼接在一起形成食管粘膜表面全景图，并在Core B中进行高级别不典型增生和早期腺癌的“红旗”识别，以协助医生指导活检。这种集成成像策略的性能将在Core c中得到验证。该仪器将通过医学内窥镜的工作通道，用于个体肽的1期临床研究

Project Summary: A multi-spectral scanning fiber endoscope (SFE) will be developed to image the panel of fluorescent-labeled pepfides developed in Project 2 that have specific binding activity to amplified and/or over expressed gene targets identifled in Project 1. Image processing algorithms will be developed to stitch together individual images to form a panorama of the esophageal mucosal surface, and "red-flag" idenfificafion of highgrade dysplasia and early adenocarcinoma will be performed in Core B to assist the physician by guiding biopsy. The performance of this integrated imaging strategy will be validated in Core C. This instrument will pass through the working channel of a medical endoscope in Phase 1 clinical studies of the individual pepfides assigned to three fiuorescent-labels in Project 2. The expected establishment of safety will prepare this system for a future multi-center clinical validation study.