Developmental Research Core

宾夕法尼亚大学TREC生存中心的发展核心将结合我们机构在肥胖症和癌症生物学方面的独特优势，专注于癌症生存，从而促进能量平衡对癌症复发影响的研究。该中心将由癌症生物系主任兼艾布拉姆森癌症中心副主任Lewis Chodosh博士和宾夕法尼亚大学糖尿病、肥胖和新陈代谢研究所副主任Rexford Ahima博士共同领导。在与宾夕法尼亚TREC中心领导层和顾问协商后，发展核心将负责征集、 优先考虑和选择发展试点项目，以探索新的想法，并利用有潜力促进现有TREC中心倡议的新机会。发展核心还将参与制定涉及多个TREC中心的跨TREC试点项目。发展核心的另一个重点将是促进有可能对TREC方案的结果产生协同影响的活动，包括从外部引进专业知识的外联努力 宾夕法尼亚大学TREC加强其研究活动，并向非TREC实体进行外联努力，以将TREC倡议的影响范围扩大到新的科学家群体。开发核心将使宾夕法尼亚大学TREC生存中心能够在其三个主要研究项目形成的概念平台上进行扩展，从而将其调查范围扩大到锻炼和肥胖对乳腺癌以外其他类型癌症复发的影响，以及整个转化研究连续过程中其他持续的不良治疗影响。该中心的具体目标是：1)实施一项试点项目计划，促进运动、肥胖和癌症存活率研究方面的创新、跨学科研究项目；2)为由宾夕法尼亚大学TREC幸存者中心资助的中心内和跨TREC试点项目提供持续支持；3.向TREC研究社区和临床肿瘤学社区传播发展研究计划的结果；以及4)评估发展研究计划的成功。

The Developmental Core ofthe Penn TREC Survivor Center will facilitate research on the effects of energy balance on cancer recurrence by combining the unique strengths of our institution in obesity and cancer biology to focus on cancer survivorship. This Core will be co-led by Dr. Lewis Chodosh, Chair of the Department of Cancer Biology and Associate Director of the Abramson Cancer Center, and Dr. Rexford Ahima, Associate Director ofthe Penn Institute for Diabetes, Obesity and Metabolism. In consultation with Penn TREC Center leadership and advisors, the Development Core will be responsible for soliciting, prioritizing and selecting developmental pilot projects to explore new ideas and capitalize on emerging opportunities that have the potential to contribute to existing TREC Center initiatives. The Developmental Core will also participate in formulating Cross-TREC pilot projects involving multiple TREC centers. An additional focus of the Developmental Core will be to promote activities with the potential to synergistically impact on outcomes ofthe TREC Program, including outreach efforts to bring in expertise from outside the Penn TREC to enhance its research activities, and outreach efforts to non-TREC entities to extend the reach of the TREC initiative into new communities of scientists. The Developmental Core will enable the Penn TREC Survivor Center to expand upon the conceptual platform formed by its three primary research projects, thereby extending the reach of its investigations to the effects of exercise and obesity on recurrence of other types of cancer beyond breast, as well as other persistent adverse treatment effects across the translational research continuum. The Specific Aims ofthe Core are: 1) To implement a pilot project program that promotes innovative, interdisciplinary research projects in exercise, obesity and cancer survivorship research; 2) To provide ongoing support for within Center and Cross-TREC pilot projects funded by the Penn TREC Survivor Center; 3. To disseminate the results ofthe developmental research program to the TREC research community and the clinical oncology community; and 4) To evaluate the success of the developmental research program.