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Bay Area Breast Cancer & the Environment Research Center

湾区乳腺癌

基本信息

批准号：
7991101
负责人：
ROBERT A HIATT
金额：
$ 9.79万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
依托单位国家：
美国
项目类别：
财政年份：
2003
资助国家：
美国
起止时间：
2003-09-29 至 2012-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7991101
关键词：
2-crotonyloxymethyl-(4R,5R,6R)-4,5,6-trihydroxycyclohex- 2-enone 8 year old Address Advocacy Area Breast California Cancer Advocacy Cells Communities Community Outreach Comprehensive Cancer Center County Data Development Developmental Biology Diagnosis Environment Environmental Risk Factor Epidemiology Etiology Exposure to Foundations Fright Government Health Health Planning In Vitro Institution Leadership Link Longevity Malignant Neoplasms Mammary gland Medical Modeling Movement Mus Physical Examination Population Sciences Predisposition Puberty Questionnaires Recruitment Activity Reporting Research Research Infrastructure Research Project Grants San Francisco Scientist Staging Time Universities Woman Work base carcinogenesis carcinogenicity cohort community based participatory research environmental stressor experience follow-up gene environment interaction girls interest malignant breast neoplasm mammary gland development member skills

项目摘要

DESCRIPTION (provided by applicant) Breast cancer remains the most common cancer for women and perhaps their most feared medical diagnosis. Although much is known about the etiology of breast cancer, questions remain about environmental factors that initiate breast cancer carcinogenesis and when they act during the lifespan. The Bay Area Breast Cancer and the Environment Research Center (BABCERC), based at the University of California San Francisco Comprehensive Cancer Center under the leadership of Dr. Robert A. Hiatt, Director of Population Sciences, will address the on-going concerns about the environmental etiology of breast cancer by focusing on mammary gland development during puberty when the breast may be especially vulnerable to environmental influences. At the same time it will create a unique organizational infrastructure for enhancing the existing partnership of scientists with local community and advocacy groups following the principles of community-based participatory research. The Bay Area is well suited for such a Center because rates of breast cancer there have been reported as the highest in the nation and there is high interest and cooperation from involved community members, government leaders, health departments, academic institutions and advocacy groups. Project 1 will study mammary cells and the mammary microenvironment in normal and cancer prone mice during all stages of development to determine the effects of exposure to prototypical environmental stressors in this model and develop in vitro mechanism-based screens to detect agents with possible mammary gland carcinogenicity. Project 2 proposes to recruit a cohort of approximately 400 7-8 year old girls from the Kaiser Foundation Health Plan and follow them through the pubertal transition. Data will be collected during a 6 year follow-up period from questionnaires, physical examination, and biospecimens that will allow analyses of links between environmental factors and mammary development, including the possible importance of susceptibility associated with selected gene-environment interactions. The Community Outreach and Translational Core will be directed and comprised of leaders in the local breast cancer advocacy movements in Marin and San Francisco Counties, who are highly experienced working with their respective communities on the topic of this research. The COTC activities are both highly integrated and interactive with the research projects and well connected to the community and its concerns. By incorporating the skills of a broad spectrum of expertise in fields such as developmental biology, epidemiology, and community advocacy, the BABCERC will provide an exciting opportunity for transdisciplinary research on a significant societal and biomedical challenge...understanding the relationship of breast cancer to the environment.

描述（由申请人提供）乳腺癌仍然是妇女最常见的癌症，也许是她们最害怕的医学诊断。虽然对乳腺癌的病因学了解很多，但关于引发乳腺癌致癌的环境因素以及它们在生命周期中何时起作用的问题仍然存在。旧金山湾区乳腺癌与环境研究中心（BABCERC），位于加州大学弗朗西斯科综合癌症中心，由罗伯特·A·卡耐基博士领导。希亚特，人口科学主任，将通过关注青春期乳腺发育来解决对乳腺癌环境病因学的持续关注，青春期乳腺可能特别容易受到环境影响。与此同时，它将建立一个独特的组织基础设施，以加强科学家与当地社区和倡导团体之间的现有伙伴关系，遵循以社区为基础的参与性研究的原则。湾区非常适合这样一个中心，因为据报道，那里的乳腺癌发病率是全国最高的，而且社区成员、政府领导人、卫生部门、学术机构和倡导团体对该中心有很高的兴趣和合作。项目1将在发育的所有阶段研究正常和癌症易感小鼠的乳腺细胞和乳腺微环境，以确定在该模型中暴露于原型环境应激源的影响，并开发基于体外机制的筛选，以检测可能具有乳腺致癌性的试剂。项目2拟从凯撒基金会健康计划中招募一批约400名7-8岁女孩，并跟踪她们的青春期过渡。将在6年随访期内从问卷调查、体格检查和生物标本中收集数据，以分析环境因素与乳腺发育之间的联系，包括与选定基因-环境相互作用相关的易感性的可能重要性。社区外展和翻译核心将由马林和弗朗西斯科县当地乳腺癌宣传运动的领导人领导和组成，他们在本研究的主题上与各自的社区合作经验丰富。 COTC的活动与研究项目高度融合和互动，并与社区及其关注的问题密切相关。通过整合发展生物学，流行病学和社区宣传等领域的广泛专业知识的技能，BABCERC将为跨学科研究提供一个令人兴奋的机会，以应对重大的社会和生物医学挑战。了解乳腺癌与环境的关系。

项目成果

期刊论文数量（20）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Evaluation of a partnership approach to translating research on breast cancer and the environment.

DOI：
10.1353/cpr.0.0081
发表时间：
2009
期刊：
Progress in community health partnerships : research, education, and action
影响因子：
0
作者：
Van Olphen J;Ottoson J;Green L;Barlow J;Koblick K;Hiatt R
通讯作者：
Hiatt R

Stromal mediation of radiation carcinogenesis.

DOI：
10.1007/s10911-010-9197-6
发表时间：
2010-12
期刊：
Journal of mammary gland biology and neoplasia
影响因子：
2.5
作者：
Barcellos-Hoff MH
通讯作者：
Barcellos-Hoff MH

Radiation acts on the microenvironment to affect breast carcinogenesis by distinct mechanisms that decrease cancer latency and affect tumor type.

DOI：
10.1016/j.ccr.2011.03.011
发表时间：
2011-05-17
期刊：
Cancer cell
影响因子：
50.3
作者：
Nguyen DH;Oketch-Rabah HA;Illa-Bochaca I;Geyer FC;Reis-Filho JS;Mao JH;Ravani SA;Zavadil J;Borowsky AD;Jerry DJ;Dunphy KA;Seo JH;Haslam S;Medina D;Barcellos-Hoff MH
通讯作者：
Barcellos-Hoff MH

Promotion of variant human mammary epithelial cell outgrowth by ionizing radiation: an agent-based model supported by in vitro studies.