利尿钠肽受体和心肌细胞生物学-猫眼课题宝

利尿钠肽受体和心肌细胞生物学

批准号：

8495787

负责人：

Margaret M Redfield

金额：

$37.04万

依托单位：

MAYO CLINIC ROCHESTER

依托单位国家：

美国

项目类别：

财政年份：

2005

资助国家：

美国

项目状态：

未结题

起止时间：

2005-08-15 至

来源：

https://reporter.nih.gov/project-details/8495787

关键词：

Ablation Acceleration Affect Attention Biology Canis familiaris Cardiac Cardiac Myocytes Cardiovascular system Catabolism Chronic Clinical Collagen Cyclic GMP Diastolic heart failure Disease Progression Dominant-Negative Mutation Elderly woman Fibrosis Foundations Functional disorder Funding Future Gene Delivery General Population Genes Guidelines Heart Heart failure High Prevalence Hospitals Human Hypertension Hypertrophy Image Impairment In Vitro Kidney Lung Mammals Medicine Modeling Mus Natriuretic Peptides Particulate Patients Peptide Receptor Peptides Phenotype Physiology Population Prevalence Principal Investigator Proteins Public Health Pulmonary Hypertension Recombinant adeno-associated virus (rAAV)Registries Reporting Residual state Rodent Serotyping Signal Transduction Stress Supportive care System Techniques Time Translations Venous Viral Wild Type Mouse atrial natriuretic factor receptor A base effective therapy improved in vivo inhibitor/antagonist mortality mutant novel novel strategies novel therapeutics overexpression phosphoric diester hydrolase pre-clinical pressure prevent professor programs protective effect protein expression receptor response restoration saluretic single photon emission computed tomography sodium-iodide symporter vector viral gene delivery

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中文摘要

翻译

项目主任/首席调查员(最后、第一、中间)：伯内特，约翰。C Jr. 项目1 题目：利钠肽受体与心肌细胞生物学项目描述：这项提议寻求开发一种新颖的、心脏特有的和最终可翻译的心脏特异性钠尿肽过度表达治疗舒张性心力衰竭通过腺相关病毒(AAV)基因传递的受体(鸟苷酸环化酶A(GCA))。我们将优化 GCA在啮齿动物心脏中的过表达，表明通过基因传递恢复心脏GCA可以防止 GCA基因缺陷小鼠(全身性心力衰竭和心脏特异性心力衰竭)的实验研究 GCAnuii)消融GCA基因)，并逆转已确诊的DHF野生型小鼠的心力衰竭。这些这些研究为今后的研究中转化为大型哺乳动物和人类DHF奠定了基础。项目负责人：玛格丽特·M·雷德菲尔德。医学博士；医学教授其他

英文摘要

Program Director/Principal Investigator (Last, First, Middle): Burnett, John. C. Jr. PROJECT 1 Title: Natriuretic Peptide Receptor and Cardiomyocyte Biology Project Descripfion: This proposal seeks to develop a novel, cardiac specific and ulfimately translatable therapy for diastolic heart failure (DHF) based on the cardiac specific over-expression of the natriuretic pepfide receptor (guanylyl cyclase A (GCA)) via adeno-associated viral (AAV) gene delivery. We will optimize overexpression of GCA in rodent heart, demonstrate that restoration of cardiac GCA via gene delivery prevents heart failure in GCA deficient mice (mice witli systemic (GCA"uit) and mice witti cardiac specific (CS- GCAnuii) ablation ofthe GCA gene) and reverses heart failure in wild type mice with established DHF. These studies lay the foundation for translation to large mammal and human DHF in future studies. Project Leader: Margaret M. Redfield. MD; Professor of Medicine Other

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