Rochester Epidemiology Project

描述（由申请人提供）：此更新申请要求支持罗切斯特流行病学项目（REP），该项目自1966年以来一直支持明尼苏达州奥姆斯特德县居民的医疗记录链接系统。这个独特的研究基础设施记录了从20世纪初到现在向社区居民提供的医疗服务，并支持了几乎所有研究设计和美国大多数疾病实体的基于人群的流行病学调查。REP支持了梅奥医疗中心，奥姆斯特德医疗中心和其他学术机构的大量研究人员的工作。并允许有效地进行外部资助的具有重大社会影响的疾病研究。REP目前支持40项政府资助的赠款，自42年前首次资助以来，已有1800多篇手稿在同行评议的文献中发表，其中包括自2005年我们上一次竞争更新以来的214篇。这个广泛的数据存储库来自地理上定义的人口，在这个国家几乎是无与伦比的，这是至关重要的，这一重要的研究基础设施被保存和扩展到未来。这笔赠款的每一个周期都提供了一个机会，不仅可以维持核心的医疗记录联系功能，而且可以增强其效用。在这个更新申请中，我们建议到2015年更新REP医疗记录链接系统（目标1）；通过将有关医疗服务和程序及其相应费用、药物处方和免疫接种的额外数据联系起来，加强全民健康覆盖基础设施（目标2）；并将REP基础设施扩展到居住在明尼苏达州东南部8个县（奥姆斯特德以及周围的道奇、菲尔莫尔、瓦巴沙、莫厄、古德休、威诺纳和休斯顿县）的更多人口；目标3)。这些新目标建立在我们在当前和以前的项目周期中取得的成就之上，包括更及时的数据收集、对历史纸质医疗记录进行大规模扫描和诊断索引、增加新的信息来源和分析方法、开发正在进行的人口普查枚举，以及开发工具以提高访问便利性，同时提供更高的数据安全性。因此，在这个更新申请中提出的目标将为越来越多的临床研究者、流行病学家、统计学家和基础科学家组成的多学科团队提供更多的数据可用性，这些团队正在解决重大的公共卫生问题。最终目标是继续支持基于人群的疾病病因学研究、预防干预、改进医疗实践和改善人群健康，如NIH路线图所概述的那样。公共卫生相关性：此更新申请要求支持罗切斯特流行病学项目（REP），该项目自1966年以来一直支持明尼苏达州奥姆斯特德县居民的医疗记录链接系统。这个独特的研究基础设施记录了从20世纪初到现在提供给社区居民的医疗保健，并支持基于人口的流行病学调查，几乎每一项研究设计和美国发生的大多数疾病实体。最终目标是继续促进基于人口的疾病病因学研究，预防干预，改善医疗实践，改善人口健康，如NIH路线图所述。

DESCRIPTION (provided by applicant): This renewal application requests support for the Rochester Epidemiology Project (REP) that has supported the medical records-linkage system for residents of Olmsted County, MN, since 1966. This unique research infrastructure chronicles the medical care delivered to community residents from the early 1900s to the present and has supported population-based epidemiologic investigations of virtually every study design and of most disease entities occurring in the U.S. The REP has supported the work of a large number of investigators at Mayo Medical Center, Olmsted Medical Center, and other academic institutions, and has permitted the efficient conduct of extramurally- funded studies of diseases with substantial societal impact. The REP currently supports 40 government-funded grants, and since its initial funding 42 years ago, more than 1,800 manuscripts have been published in the peer-reviewed literature, including 214 since our last competing renewal in 2005. This extensive data repository from a geographically-defined population is virtually unparalleled in this country, and it is essential that this important research infrastructure be preserved and extended into the future. Each cycle of this grant has presented an opportunity to not only maintain the core medical records-linkage function, but also to enhance its utility. In this renewal application, we propose to update the REP medical records-linkage system through 2015 (Aim 1); to enhance the REP infrastructure by linking additional data on medical services and procedures and their corresponding costs, drug prescriptions, and immunizations (Aim 2); and to expand the REP infrastructure to the larger population of individuals residing in the 8-county region of southeastern Minnesota (Olmsted plus surrounding Dodge, Fillmore, Wabasha, Mower, Goodhue, Winona, and Houston counties; Aim 3). These new aims build on our accomplishments from the current and previous project cycles that include more timely data collection, massive scanning and diagnostic indexing of historical paper medical records, addition of new sources of information and analytic methods, development of an ongoing census enumeration, and development of tools to increase ease of access while providing greater data security. Thus, the aims proposed in this renewal application will provide increased data availability for the growing number of multidisciplinary teams of clinical investigators, epidemiologists, statisticians, and basic scientists who are addressing significant public health questions. The ultimate goal is to continue to support population-based research of disease etiology, preventive interventions, improved medical practice, and better health for the population, as outlined in the NIH Roadmap. PUBLIC HEALTH RELEVANCE: This renewal application requests support for the Rochester Epidemiology Project (REP) that has supported the medical records-linkage system for residents of Olmsted County, MN, since 1966. This unique research infrastructure chronicles the medical care delivered to community residents from the early 1900s to the present and supports population-based epidemiologic investigations of virtually every study design and of most disease entities occurring in the U.S. The ultimate goal is to continue to facilitate population-based research of disease etiology, preventive interventions, improved medical practice, and better health for the population, as outlined in the NIH Roadmap.