核心 D：神经病理学和动物行为-猫眼课题宝

核心 D：神经病理学和动物行为

批准号：

8292294

负责人：

ELIEZER MASLIAH

金额：

$10.02万

依托单位：

SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

依托单位国家：

美国

项目类别：

财政年份：

2011

资助国家：

美国

项目状态：

已结题

起止时间：

2011-07-01 至 2013-06-30

来源：

https://reporter.nih.gov/project-details/8292294

关键词：

Alzheimer&apos s Disease Animal Behavior Animal Model Anterior Apoptosis Autopsy Behavioral Biochemical Biological Preservation Brain Brain Stem Brain region Cell model Characteristics Clinical Cognitive Complex Consensus Consultations Data Dementia Detergents Development Diagnosis Disease Drosophila genus Equilibrium Experimental Designs Freezing Fresh Tissue Genes Glial Fibrillary Acidic Protein Grant Guidelines Hippocampus (Brain)Housing Human Immunoblotting In Vitro Injection of therapeutic agent Investigation Laboratories Lentivirus Vector Lewy Body Disease Microtubule-Associated Protein 2 Mission Modeling Modification Molecular Motor Mus Mutation National Institute of Environmental Health Sciences Necrosis Neocortex Nerve Degeneration Neurons PTEN gene Parkinson Disease Parkinson&apos s Dementia Parkinsonian Disorders Pathogenesis Pathologic Pathway interactions Patients Pattern Performance Phosphorylation Phosphotransferases Platelet-Derived Growth Factor Play Principal Investigator Process Proteins RNA Research Research Support Role Saccharin Sampling Self Administration Staging Staining method Stains Synapses Synaptophysin Techniques Testing Time Tissues Transgenic Animals Transgenic Mice Tyrosine 3-Monooxygenase Visual alpha synuclein brain tissue calbindin density dopamine transporter embryonic stem cell human embryonic stem cell human tissue in vitro Model in vivo leucine-rich repeat kinase 2 motor learning mouse model mutant neocortical nerve stem cell neuropathology overexpression parkin gene/protein programs promoter protein aggregate protein misfolding protein protein interaction small molecule therapy development thioflavine tissue fixing

项目摘要

项目成果

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中文摘要

翻译

神经病理学和动物行为核心的使命是提供以下项目： NIEHS中心也有来自人类PD病例的特征良好的尸检大脑材料与表达α-突触核蛋白（α-syn）、DJ-1、Parkin和PINK 1的转基因（tg）动物模型一样用于神经病理学、分子学、生物化学和行为学研究。核心将提供为项目1、2和3提供PD患者和PD动物模型的人体组织支持; 支持项目3中的行为研究;并帮助进行存活/凋亡/坏死分析，人胚胎干细胞（hESC）衍生的发育中的神经元项目4。核心开发了用于神经变性的神经病理学分析的最新技术，错误折叠蛋白质积累的生化分析，以及运动和认知改变此外，我们还开发了独特的PD动物模型，筛选新的分子途径和小分子。请注意，人类临床 NIEHS中心RFA中定义的组件包含在本核心中。

英文摘要

The mission of the Neuropathology and Animal Behavior Core will be to provide the projects of the NIEHS Center with well-characterized autopsy brain material from human PD cases as well as with transgenic (tg) animal models expressing a-synuclein (a-syn), DJ-1, Parkin and PINK1 for neuropathological, molecular, biochemical and behavioral studies. The Core will provide support with human tissues from PD patients and animal models of PD to Projects 1, 2, and 3; support behavioral studies in Project 3; and help with survival/apoptosis/necrosis analysis of human embryonic stem cell (hESC)-derived developing neurons for Project 4. The Core has developed state of the art techniques for neuropathological analysis of neurodegeneration, biochemical analysis of misfolded protein accumulation, and behavioral analysis of motor and cognitive alterations. Moreover, we have developed unique animal models of PD in which to test and screen new molecular pathways and small molecules. Please note that a human clinical component, as defined in the NIEHS Center RFA, is contained within this Core.

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