Pilot Projects Component

该试点项目旨在将新的研究人员带入酒精领域 研究--通过以下方式提供资金：(A)向年轻调查人员提供资金；(B)向提议 偏离其正在进行的研究的项目。这项计划的资金将足以获得试点 可用于支持独立研究拨款申请的数据或可为未来提供种子的数据 再次申请解除弧光资金。竞争试点资金的过程包括内部征集 建议和依赖于内部和外部审查的严格审查程序，以选择关于 最好的品质。这一过程在管理核心中进行了描述。 我们已拨出八个试验项目的时段，两个项目将在#年的首四年每年展开。 解除弧线的资金。目前的申请列出了四个潜在的试点项目，它们已经通过了我们的 内部和外部审查流程。其他项目一直处于开放状态，以保持活力和 酒精研究领域的流动性(尽管描述中包括了两个潜在的项目)。 最初的三项研究如下。(1)罗素·马修斯(副教授，系)神经科学和 生理学，北部)是细胞外基质在神经系统发育中的作用的专家。他 建议研究产前接触乙醇对发育中的塑料事件的影响。 在躯体感觉皮质中的桶。(2)John Lombardo(教授，系)心理学，纽约州立大学科特兰分校)研究 多氯联苯的毒性。他将探讨的问题之一是围产期的影响 暴露于多氯联苯可增加酒精摄入量对性二型性的影响。(3)Sandra Mooney(副教授，系) 神经科学和生理学，北部)正在研究胎儿编程。她建议曝光 在关键时刻饮用酒精，无论是原肠形成还是神经元形成，都会导致长期的社会行为改变。 青少年。(4)Michael Nishnikov(宾厄姆顿大学讲师)将探讨 Kappa阿片受体(A)作为围产期酒精暴露的媒介和(B)在乙醇中作为一种 胃口/厌恶的物质。每个拟议的试点项目都与至少一个主要 项目，并使用至少两个科学核心。 总而言之，试点项目计划将作为新中部地区酒精研究的种子 约克市。这将鼓励新的研究人员和新的想法来探索酒精毒性在神经发育中的作用 系统。

The PILOT PROJECT PROGRAM is designed to bring new investigators into the field of alcohol research-by providing funds (a) to young investigators and (b) to established investigators who propose projects departing from their ongoing research. Funding from this program will be sufficient to obtain pilot data that can be used to support applications for independent research grants or can seed future reapplications for DEARC funding. The process for competing for pilot funding includes internal solicitation of proposals and a rigorous review process relying on internal and external reviews to select studies of the highest quality. This process is described in the ADMINISTRATIVE CORE. We have allotted eight slots for Pilot Projects, two projects will commence in each of the first four years of the DEARC funding. The current application lists four potential pilot projects that have passed through our internal and external review processes. The other projects have been left open to allow for the vibrancy and fluidity of the field of alcohol research (though two potential projects have been included in the description). The initial three studies are as follows. (1) Russell Matthews (Asst. Prof., Dept. of Neuroscience and Phyiology, Upstate) is an expert in the role of extracellular matrix in the developing nervous system. He proposes to examine the effects of prenatal exposure to ethanol on plastic events in the development of barrels in somatosensory cortex. (2) John Lombardo (Prof., Dept. of Psychology, SUNY- Cortland) studies the toxicity of polychlorinated biphenyls. Among the issues that he will explore is the effect of perinatal exposure to PCBs to increase ethanol intake on sexual dimorphisms. (3) Sandra Mooney (Asst. Prof., Dept. of Neuroscience and Physiology, Upstate) is investigating fetal programming. She proposes that exposure to ethanol at a key time, gastrulation or neuronogenesis, can lead to long-term changes in social behavior in adolescents. (4) Michael Nishnikov (Instructor, Binghamton University, Binghamton) will explore the role of kappa opioid receptors (a) as mediators of perinatal ethanol exposure and (b) in ethanol acting as an appetitive/aversive substance. Each of the proposed Pilot Projects integrates with at least one MAIN PROJECT and uses at least two of the scientific CORES. In summary, the PILOT PROJECT PROGRAM will serve as the seed for alcohol research in Central New York. It will encourage new researchers and new ideas to explore ethanol toxicity in developing nervous systems.