Studies of Organ Transplantation in Animals and Man

总体描述(由申请人提供)：这是一份已生效39年的计划项目资助的竞争性续签申请。它涉及许多研究人员和许多不同的项目，都与改善实体器官移植的结果有关。 这笔赠款的基本总体目标是： A.隔离和分析实体器官移植的临床问题，并准确记录临床/实验室相关性； B.根据现有数据组织临床试验和实验方法，以帮助解决临床问题。 在这些目标范围内，目前赠款上的所有项目都分为两个具体目标： 1.防止器官破坏。这不仅包括旨在防止排斥反应和免疫性移植物丢失的免疫操作，也包括旨在防止非免疫性移植物丢失、延长受体存活以及修改或控制药物毒性和复发疾病的免疫操作。 2.最大限度地促进康复。这里的重点是最大限度地减少并发症和最大化生活质量。

DESCRIPTION, OVERALL (provided by applicant): This is an application for competitive renewal of a Program Project Grant that has been active for 39 years. It involves many investigators and many different projects, all relating to the improvement of the results of solid organ transplantation. The basic overall OBJECTIVES of this grant are to: A. isolate and analyze clinical problems in solid organ transplantation and precisely document clinical/laboratory correlations; B. organize clinical trials and experimental approaches based on available data to help solve clinical problems. Within these objectives, all projects on the current grant are organized into two specific AIMS: 1. To prevent organ destruction. This includes not only immunologic manipulations designed to prevent rejection and immunologic graft loss, but also those designed to prevent nonimmunologic graft loss, to prolong recipient survival, and to modify or control drug toxicity and recurrent disease. 2. To maximize rehabilitation. The focus here is on minimizing complications and maximizing quality of life.