In Vivo Imaging of Neoplasia

概述：在最初的资助期间，该计划通过其研究人员的共同创造性努力，在分子成像方面取得了重大进展。分子成像的这些进展导致了新的分子成像报告分子的发展，这些分子已经被用来提高我们对癌症病因、生物学、病理生理学和治疗的理解。在这次更新的ICMIC应用中，我们将继续开发先进的方法来成像体内存在的癌前(发育不良)组织和致癌信号分子。项目1将开发一种集成的光学分子成像策略，该策略使用荧光肽作为探针来定位体内存在的癌前(发育不良)组织。该项目将开发新的光学成像探头和仪器，可用于临床前模型，并可转化为临床上用于早期发现中空器官癌症的实用筛查工具。项目2将开发和验证分子成像报告器(即EGFR、Met和Akt)。在细胞和动物中的非侵入性成像将被用于评估这些新的报告结构，以检测关键的致癌信号通路。项目3将开发分子成像工具，用于对胶质瘤的信号通路进行成像，并对胶质瘤干细胞亚群进行成像。这些工具和概念将大大有助于我们的临床前药物开发过程，并为脑瘤更有效的联合治疗策略提供见解。该提案包括一项职业发展计划，该计划提供了培训年轻、热情的分子成像研究人员并与其互动的机会。该试点计划将通过提供资金、想法和资源来促进正在进行的研究，从而使杰出的科学家能够被招募到分子成像领域。作为核心A，行政核心将为所有项目提供行政和统计支助，并将促进对所有项目的外部和内部科学审查。成像核心(核心B)将为ICMIC的所有动物成像需求提供成像专业知识和设备。生物统计核心(核心C)将提供所有项目、试点项目和职业发展奖获得者的所有生物统计分析。UM-ICMIC方案的中心目标之一是弥合巨大的鸿沟 在癌症研究中，高质量的病人护理和实验室研究之间的差距。这仍然是当前提案的驱动力。

OVERVIEW: During the initial funding period, the program has made significant advances in molecular imaging through the combined creative efforts of its investigators. These advances in molecular imaging have led to the development of novel molecular imaging reporter molecules which have been used to improve our understanding of cancer etiology, biology, pathophysiology and therapy. In this renewal ICMIC application, we will continue to develop cutting edge approaches for imaging the presence of pre-malignant (dysplastic) tissue and oncogenic signaling molecules in vivo. Project 1 will develop an integrated optical molecular imaging strategy that uses fluorescence peptides as probes to target the presence of premalignant (dysplastic) tissue in vivo. This Project will develop novel optical imaging probes and instruments that can be used in pre-clinical models as well as translated to the clinic as practical screening tools for the early detection of cancer in hollow organs. Project 2 will develop and validate molecular imaging reporters (i.e. EGFR, Met and Akt). Non-invasive imaging in cells and animals will be used to evaluate these novel reporter constructs for detection of key oncogenic signaling pathways. Project 3 will develop molecular imaging tools for imaging of signaling pathways in gliomas and for imaging of the glioma stem cell subpopulation. These tools and concepts should significantly aid in our preclinical drug development process and provide insights into more efficacious combination therapy strategies for brain tumors. The proposal includes a Career Development Program which provides the opportunity to train and interact with young, enthusiastic molecular imaging investigators. The Pilot Program will enable recruitment of outstanding scientists to the molecular imaging field by providing funding, ideas and resources to facilitate ongoing research. Core A, the administrative core will provide administrative and statistical support to all projects and will also facilitate External and Internal scientific review of all projects. The imaging Core (Core B) will provide imaging expertise and equipment for all of the animal imaging needs of this ICMIC. The Biostatistics Core (Core C) will provide for all of the biostatistical analysis of all of the Projects, Pilot Projects and Career Development Awardees. One of the central goals of the UM-ICMIC program is to bridge the great divide between quality patient care and laboratory studies in cancer research. This continues to be the driving force in the current proposal.