CB: Tissue Core

COREB：标本 亚利桑那大学和罗切斯特大学的联合组织资源核心将拥有 收集、储存和编目患者的病理标本的责任 在亚利桑那州和詹姆斯·P·威尔莫特癌症中心看到的淋巴增殖性疾病 分别是亚利桑那大学和罗切斯特大学。此外，核心还将收集和存储正常 淋巴组织、血液和骨髓细胞用作使用 相应的恶性组织。标本以快速冰冻块、石蜡块、活细胞的形式存储 悬浮液和冰冻血清等份。组织采购和数据收集是在 IRB在每个机构批准的方案。所有患者都必须在签署知情同意书之前 使用严格保持患者匿名的程序提取临床或流行病学信息 这符合《健康保险可携带性和责任法》(HIPAA)确立的指导方针。 此外，在阿肯色州大学，未经同意的患者的多余诊断组织被存储为例行公事 练习一下。如果没有IRB的直接批准和豁免，不会提取这些患者的临床信息 知情同意。然而，这些组织更频繁，并成为有价值的检测样本 发展和可行性研究。血液淋巴样细胞系的库也保持活跃 收集感兴趣的新细胞系。这些设施已经在以下方面相互集成 样本分发和软件开发。组织资源核心的总体目标是提供 必要的患者样本和细胞系，以支持淋巴瘤孢子翻译研究项目。 具体目标是： 1.同意、收集、储存和批注高质量样品，符合 以便最大限度地发挥其潜在作用； 2.通过病理评估、免疫表型、分子研究和 临床特点； 3.通过仔细的库存控制、创建组织微阵列、预先提取 DNA和RNA； 4.及时有效地分发样本，最大限度地发挥翻译研究的潜力。 亚利桑那大学和罗切斯特大学的这些联合资源将密切参与每一项 本次孢子赠款申请中提出的项目，并将促进 在孢子内外投射。

COREB: SPECIMEN The combined Tissue Resource Core at the Universities of Arizona and Rochester will have the responsibility of collecting, storing and cataloging pathological specimens from patients with lymphoproliferative disorders that are seen at the Arizona and James P Wilmot Cancer Centers at the Universities of Arizona and Rochester respectively. In addition, the Core will also collect and store normal lymphoid tissue and blood and bone marrow cells to be used as controls for biologic studies that use the corresponding malignant tissue. Specimens are stored as snap frozen blocks, paraffin blocks, viable cell suspensions, and frozen serum aliquots. Tissue procurement and data collection is done under the auspices of IRB approved protocols at each institution. All patients are required to sign an informed consent before abstracting clinical or epidemiologic information using procedures that maintain strict patient anonymity and that adhere to the guidelines established by the Health Insurance Portability and Accountability Act (HIPAA). In addition, at U of A, excess diagnostic tissue from non-consented patients is stored as a matter of routine practice. No clinical information is abstracted on these patients without direct IRB approval and waiver of informed consent. However, these tissues are more frequent and make valuable samples for test development and feasibility studies. A bank of hematolymphoid cell lines is also maintained with active collection of new cell lines of interest. These facilities are already integrated with each other regarding sample distribution and software development. The overall goal of the Tissue Resource Core is to provide necessary patient samples and cell lines to support the Lymphoma SPORE translational research projects. The specific aims are: 1. To consent, collect, store, and annotate high quality samples in accordance with regulatory guidelines in order to maximize their potential usefulness; 2. To characterize samples through pathologic evaluation, immunophenotyping, molecular studies, and clinical features; 3. To conserve tissues through careful inventory control, creation of tissue microarrays, up-front extraction of DMA and RNA; 4. To distribute samples in a timely and efficient manner to maximize their translational research potential. These combined resources at the University of Arizona and Rochester will be intimately involved with each of the projects proposed in this SPORE grant application and will facilitate the development of collaborative projects within and beyond the SPORE.