FASEB SRC on Skeletal Muscle Satellite and Stem Cells

描述（由申请人提供）：本申请为即将于2012年8月12日至17日在意大利卢卡举行的美国实验生物学学会联合会（FASEB）题为“骨骼肌卫星和干细胞”的会议寻求部分支持。我们预计约有185名来自世界各地的与会者。本次会议的总体目标是强调有关肌源性干细胞和祖细胞群体（如卫星细胞）的调节机制及其在发育、再生、肥大、衰老和肌病状态中的作用的最新进展。这将是第七届聚焦卫星细胞/干细胞和肌肉再生的会议。从第一届会议到第六届会议参与人数的增加表明有必要召开一次专门讨论卫星细胞和干细胞的会议。从前六次会议的成功可以清楚地看出，这一主题引起了人们的高度兴趣，这次会议是唯一一次直接讨论肌肉卫星细胞和干细胞群体的会议。两年一次的多学科时间

DESCRIPTION (provided by applicant): This application seeks partial support for the upcoming Federation of American Societies of Experimental Biology (FASEB) conference entitled, Skeletal Muscle Satellite and Stem cells, that will be held on August 12-17, 2012 in Lucca, Italy. We expect approximately 185 attendees from around the world. The overall objective of this meeting is to highlight recent advances pertaining to the regulatory mechanisms of myogenic stem cell and progenitor cell populations (such as satellite cells) and their role in development, regeneration, hypertrophy, aging and myopathic states. This will be the 7th conference focused on satellite cells/stem cells and muscle regeneration. The increased participation from the first to the sixth meetings has demonstrated the need for a conference dedicated to satellite and stem cells. It is clear from the successes of the previous six meetings that this topic is of high interest and this meeting represents the only conference that directly addresses muscle satellite and stem cell populations. The biennial timing of this multidisciplinary conference has facilitated the presentation of new unpublished data that has generated considerable discussion and promoted collaborative interactions. Eight plenary sessions presenting 44 speakers (16 to be selected from submitted abstracts) at the senior, mid-level and junior levels will address: epigenetic and post- transcriptional control of satellite cells, non-myogenic cells in muscle that influence satellite cell biology, biology of satellite cells in the had muscles, satellite cell quiescence, activation and self-renewal, the molecular control of myogenic lineage progression and differentiation, satellite cells in growth and hypertrophy, and satellite cells in aging and disease. Three dedicated poster sessions that feature these and related topics will be held. Importantly, the participants of this conference will represent interdisciplinary groups that will provide a comprehensive analysis and integration of recent discoveries for the field. The conference will further promote collaborative interactions in an attempt to promote future advancements and translational initiatives directed toward the treatment and cure of patients with myopathic diseases. PUBLIC HEALTH RELEVANCE: The aim of this conference is to highlight recent advances pertaining to the regulatory mechanisms of myogenic stem cells and their role in growth, regeneration, and therapeutics. Understanding the biology of satellite cells and other muscle-derived stem cells at the molecular and cellular levels will lead to new insights that will hasten development of therapeutic approaches to treating disease, injuries and aging of skeletal muscle.