2009 Insulin-like Growth Factors in Physiology and Disease Gordon Conference

摘要 这项提议要求部分支持作为戈登研究会议系列的一部分的生理学和疾病中的胰岛素样生长因子国际会议，会议将于2009年3月22日至27日在加利福尼亚州文图拉举行，随后的会议将于2011年和2013年举行。会议的广泛和长期目标是增加我们对控制这些蛋白质在人类生物学和疾病中的作用的基本机制的了解。这次会议的具体目标将是召集25位代表胰岛素样生长因子(IGF)研究关键领域的演讲者，总共135人，在相对孤立的环境中举行为期五天的会议。该计划将有一个主题演讲和八个会议，将讨论当前的IGF生物学问题，涉及衰老和与年龄相关的疾病、再生医学、癌症(包括肿瘤发生、癌症进展和靶向治疗)、心血管生物学(包括对血管平滑肌发育和病理的控制，以及对心肌肥大的调控)、代谢调节(特别是控制中间代谢的信号转导通路)以及IGFS、其受体和结合蛋白在正常生理和人类疾病中的表达和功能的其他方面。此外，四个下午的海报会议将允许所有参与者就这些主题发表意见。这项申请的意义在于，戈登生理学和疾病中的胰岛素样生长因子研究会议是推动国际IGF科学界研究的定期会议的关键组成部分。这项应用的健康相关性在于，本次戈登研究会议上的讨论将确定一些关键问题，这些问题需要在影响人类发育和衰老、骨骼、骨骼肌肉和其他组织的再生和修复、癌症治疗、心脏和血管发育和疾病以及正常生理和疾病中的葡萄糖、脂肪和氨基酸代谢控制的领域中得到实验解决。

Abstract This proposal requests partial support for an international meeting on Insulin-like Growth Factors in Physiology and Disease as part of the Gordon Research Conference series, and will be held in Ventura, California during March 22 - 27, 2009, with subsequent meetings in 2011 and 2013. The Broad and Long-term Goals of the conference are to increase our understanding of the fundamental mechanisms controlling the actions of these proteins in human biology and disease. The Specific Aims of this meeting will be to convene 25 speakers who will represent critical areas of insulin-like growth factor (IGF) research with a total of 135 participants for a five-day conference in a relatively isolated setting. The program will have a keynote address and eight sessions, which will address current issues in IGF biology as they pertain to aging and age-related diseases, regenerative medicine, cancer (including tumorigenesis, cancer progression, and targeted therapeutics), cardiovascular biology (including control of vascular smooth muscle development and pathology, and regulation of myocardial hypertrophy), metabolic regulation (specifically signal transduction pathways controlling intermediary metabolism), and other aspects of the expression and function of IGFs, their receptors, and binding proteins in normal physiology and human disease. In addition, four afternoon poster sessions will permit all participants to contribute to these topics. The Significance of this application is that the Gordon Research Conference on Insulin-like Growth Factors in Physiology and Disease is a critical component of regular meetings that propels research in the international IGF scientific community. The Health Relatedness of this application is that discussions at this Gordon Research Conference will define key questions that require experimental resolution in areas that affect human development and aging, regeneration and repair of bone, skeletal muscle, and other tissues, cancer therapy, cardiac and vascular development and disease, and the control of glucose, fat, and amino metabolism in normal physiology and disease.