Animal Core

动物中心将继续为每个项目的调查人员提供协助，开展 涉及动物的研究。核心将提供与所有项目密切相关的专业知识重点，还 高效利用宝贵资源。核心的PI，E.Keller博士在前列腺方面有丰富的经验 前列腺癌的异种移植发展和包括腔内和心内在内的啮齿动物模型 注塑模型。凯勒博士将监督核心的科学方向。核心的日常活动 将由Jill Keller博士监督，他是美国实验动物医学院的认证兽医。 动物核心活动包括： -创建用于项目的动物模型。例如，椎体植入术 小白鼠将由动物核心进行血管模型的制作。 --协助动物实验。核心人员将协调和协助或指导 执行标准化程序，如腔内和心内注射、麻醉、 等。 为动物研究提供成像能力。核心将进行Faxitron射线照相，骨骼 密度法(Dexa或pQCT)和生物发光。 -根据各种项目的需要，维护各种专业老鼠的繁育群体。 特定的转基因小鼠将按要求进行维护。 -开发新的骨转移动物模型。J·凯勒博士将测试异种移植和细胞 起源于前列腺孢子的品系具有作为骨骼转移模型的能力。

The Animal Core will continue to provide investigators of each project with assistance in the conduct of research involving animals. The core will provide a focus of expertise that is germane to all projects and also efficiently utilize valuable resources. The core's PI, Dr. E. Keller has extensive experience with prostate cancer xenograft development and rodent models of prostate cancer including intratibial and intracardiac injection models. Dr. Keller will oversee the scientific direction of the core. The core's day-to-day activities will be overseen by Dr. Jill Keller, an American College of Laboratory Animal Medicine certified veterinarian. The Animal Core activities include: - Creating animal models to be used for the projects. For example, implantation of vertebrae of mice to create vossicle models will be performed by the Animal Core. - Assisting with animal experiments. Core personnel will coordinate and assist or instruct in the performance of standardized procedures such as intratibial and intracardiac injection, anesthesia, etc. Providing imaging capability for animal studies. The core will perform faxitron radiographs, bone densitometry (Dexa or pQCT), and bioluminescence. - Maintaining breeding colonies for various specialized mice as required for various projects. Specific genetically-modified mice will be maintained as required. - Development of new animal models of bone metastasis. Dr. J. Keller will test xenografts and cell lines derived from the Prostate SPORE for their ability to serve as models of skeletal metastasis.