CENTRAL SYMPATHETIC REGULATION OF THERMOGENESIS IN FEVER

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 了解中枢神经机制介导发热和寒冷的防御将 与开发治疗方法以对抗危及生命的过度发热（如在脓毒症、毒血症、脑膜炎、某些癌症期间）和管理在临床上显著的状况（如滥用基于苯丙胺的药物、伴随绝经和前列腺手术的潮热或在手术麻醉期间诱导的体温过低）期间发生的热失调的影响有关。本项目的目的是阐明调节体温的中枢神经系统回路以及它们如何受到热原的影响。 最近的研究结果包括确定一个有效的BAT交感神经抑制区在延髓腹外侧，证明一个有效的BAT兴奋作用后，应用神经肽Y到喙中缝苍白和描绘控制颤抖产热的途径。所需的慢病毒和激光设备已经获得，慢病毒注射到大鼠脑干已经成功完成。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Understanding of the central neural mechanisms mediating fever and cold defense will be relevant for developing therapeutic approaches to combat life-threatening excessive fevers (as during sepsis, toxemia, meningitis, some cancers) and to the management of the effects of thermal dysregulation that occurs during such clinically significant conditions as the abuse of amphetamine-based drugs, the hot flashes accompanying menopause and prostate surgery or the hypothermia induced during surgical anesthesia. The aims of this project are to elucidate the CNS circuits that regulate body temperature and how they are affected by pyrogens. Recent findings include the identification of a potent BAT sympathoinhibitory region in the ventrolateral medulla, the demonstration of a potent BAT excitatory effect following application of neuropeptide Y into the rostral raphe pallidus and the delineation of pathways controlling shivering thermogenesis. The required lentivirus and laser equipment have been obtained and lentivirus injections into the rat brainstem have been accomplished successfully.