CENTRAL REGULATION OF SYMPATHETIC ACTIVITY TO BROWN FAT

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 平衡能量消耗与能量摄入、代谢需求和能量储存对于维持体重、对于对代谢信号如葡萄糖、胰岛素和瘦素的持续响应以及对于许多身体系统的稳态调节是至关重要的。我们的实验是定义和测试的假设，在BAT的能量消耗是一个潜在的水槽消耗多余的能量摄入，以防止多余的能量储存在白色脂肪组织。定义能量传入信号通路以及控制BAT能量消耗效应器的传出神经通路将有助于我们理解体重和能量底物可用性的调节，并有助于设计治疗策略以控制导致肥胖、糖尿病和高血压等疾病的身体能量稳态紊乱。 最近的研究结果包括在延髓腹外侧区的神经元的鉴定，作为具有一个强大的交感神经抑制作用的BAT交感神经流出和证明，应用神经肽Y到头中缝苍白elvandus的BAT交感神经活动和BAT产热和体温增加的有力的兴奋。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Balancing energy expenditure with energy intake, metabolic requirements and energy storage is critical for maintenance of body weight, for sustained responsiveness to metabolic signals such as glucose, insulin and leptin and for homeostatic regulation of many body systems. Our experiments are defining and testing the hypothesis that energy expenditure in BAT is a potential sink for the consumption of surplus energy intake to prevent excess energy storage in white adipose tissue. Defining energy afferent signaling pathways, as well as those efferent neural pathways controlling the BAT energy expenditure effector will contribute to our understanding of the regulation of body weight and of energy substrate availability and to the design of therapeutic strategies to control disturbances in body energy homeostasis that result in diseases such as obesity, diabetes and hypertension. Recent findings include the identification of neurons in the ventrolateral medulla as having a potent sympathoinhibitory effect on BAT sympathetic outflow and the demonstration that application of neuropeptide Y into the rostral raphe pallidus elicits a potent excitation of BAT sympathetic nerve activity and BAT thermogenesis and increases in body temperature.