CORE--Clinical Research Skills Development

我们建议在翻译研究中建立一个新的教育项目，即临床研究技能 开发核心，以满足这些需求。我们早已认识到“团队精神”的重要性。 通过整合基础科学家解决儿童肺动脉高压的临床问题 来自不同领域的临床医生和科学家。除了在实验室和临床领域的成功之外，我们的 该计划进一步为无数年轻人的辅导和职业发展提供了环境 临床医生-科学家，包括我们目前的项目负责人Ivy博士和Kinsella博士。在最近的过去，我们的NIH SCOR计划进一步成为正在进行的NIH T32儿科培训计划的重要资源 肺医学(Abman博士；Pi)和心血管生物工程(Shandas博士；Pi)。 因此，临床研究技能发展核心的总体目标是开发一个更正式的 儿童肺动脉高压的教育和培训计划，可以集思广益 高度协作、多学科的调查人员，以扩大我们更好地培训年轻一代的能力 临床医生--从事转译研究的科学家。我们已经概述了一项计划，以发展新的研讨会、讲习班和 培训以疾病和患者为中心的研究方法，吸收有经验的研究人员 来自不同的领域。随着遗传学和基因组学、蛋白质组学、结果研究和 相关领域，我们计划将来自我们机构内部和其他领域的主要领导人聚集在一起 学术健康中心。这一做法反映在我们当前申请中概述的新项目中。为 例如，人类遗传学主任理查德·斯普林茨博士和遗传科主任吉尔·诺里斯博士 流行病学，现在第一次积极致力于将他们的专业领域应用于 儿童肺动脉高压问题(项目2)。此外，克拉波博士，项目的积极参与者 4将在氧化剂研究中架起长凳与床边缺口之间的桥梁。他们将使用最新的K23 获奖者或申请者(Peter Mourani医学博士和Marci Sontag博士)以及其他高级临床科学家 在SCCOR计划中。临床研究技能开发核心的增加将提供 正式结构，以加强互动和培训机会，这将导致高技能的临床 能够更好地将包括遗传学和遗传流行病学在内的多种技能应用于儿科的研究人员 肺血管疾病。如建议书所述，我们计划提供严谨的培训架构，以带来 与健康结果研究、临床试验设计、临床生理学、 生物信息学等领域。为了进一步加强培训氛围，我们计划在 科学诚信和道德，沟通技巧，导师，职业发展，以及其他关键话题。 该项目将由Abman博士负责协调，他在指导和培训方面拥有丰富的经验 作为儿科心肺中心主任和NIH T32计划在儿科肺科的PI 医药。他将与斯滕马克博士、项目负责人和合作科学家密切合作，开发出 这个核心计划。

We propose to establish a new educational program in translational research, the Clinical Research Skills Development Core, to address these needs. We have long-recognized the importance of the "team approach" for attacking the clinical problem of pediatric pulmonary hypertension through the integration of basic scientists from diverse fields with clinician-scientists. In addition to successes in the laboratory and clinical arenas, our program has further provided the environment for mentoring and career development of numerous young clinician-scientists, including 2 of our current project leaders, Drs. Ivy and Kinsella. In the recent past, our NIH SCOR program has further served as an important resource for ongoing NIH T32 training programs in pediatric pulmonary medicine (Dr. Abman; PI) and cardiovascular bioengineering (Dr. Shandas; PI). Thus, the overall goal of the Clinical Research Skills Development Core is to develop a more formal educational and training program in pediatric pulmonary hypertension, which can bring together the strengths of highly collaborative, multidisciplinary investigators, in order to expand our ability to better train young clinician-scientists in translational research. We have outlined a plan to develop new seminars, workshops and training approaches to disease- and patient- oriented research that incorporates experienced investigators from diverse fields. With rapid advances in genetics and genomics, proteomics, outcomes research, and related fields, we plan to bring together major leaders in these fields from within our institution and from other academic health centers. This approach is reflected in the new projects outlined in our current application. For example, Dr. Richard Spritz, the Director of Human Genetics, and Dr. Jill Norris, Head of Genetic Epidemiology, are now, for the first time, actively engaged in the application of their areas of expertise to the problem of pediatric pulmonary hypertension (Project 2). In addition, Dr. Crapo, an active participant in Project 4 will be available to bridge the bench to bedside gap in oxidant research. They will be working with recent K23 awardees or applicants (Drs. Peter Mourani, MD, and Marci Sontag, PhD), along with other senior clinicianscientists in the SCCOR Program. The addition of the Clinical Research Skills Development Core will provide a formal structure to enhance interactions and training opportunities, which will lead to highly-skilled clinical investigators who can better apply numerous skills including genetics and genetic epidemiology to pediatric pulmonary vascular disease. As outlined in the proposal, we plan to provide rigorous training structure to bring together clinician-scientists with leaders in health outcomes research, clinical trial design, clinical physiology, bioinformatics and other fields. To further enhance the training atmosphere, we plan formal workshops in scientific integrity and ethics, communication skills, mentorship, career development, and other critical topics. This program will be co-ordinated by Dr. Abman, who has extensive experience with mentorship and training as Director of the Pediatric Heart Lung Center and the PI of the NIH T32 Program in pediatric pulmonary medicine. He will work closely with Dr. Stenmark, the Project Leaders and collaborating scientists to develop this Core program.