Joint Center for Structural Genomics

结构基因组学联合中心（JCSG）的目标是作为一个项目参与NIGMS PShBiology项目。 高密度结构测定中心。JCSG高通量（HT）平台组装 在过去的十年中，将有效地提供大量的蛋白质结构的社区， 晶体学和核磁共振对从细菌到人类的广泛目标，包括具有挑战性的 靶点如真核蛋白质、蛋白质-蛋白质和其它大分子复合物。在整个 PSLBiology，JCSG将适应和调整其业务，以实现其发展的计划目标 进化JCSG将继续开发新的技术和方法，包括实验性的和 计算，以解决将提出的目标范围，同时保持每个结构的成本， 最低和质量的最高标准。PSI网络内的整合将是一个高度优先事项， 拥抱与生物学伙伴关系中心，未来的PARS和社区的互动，以及 支持所有PSI网络活动，包括PSI-SGKB和PSI-MR。 丰富的经验，制定最佳战略，以提高成功的机会，并消除那些 导致失败。对《防扩散安全倡议》最初的使命作出贡献， 蛋白质宇宙将通过明智的目标选择，以及工具和 合作，促进解剖整个网络，途径和分子机制， 从结构的角度来看，生物或细胞。生物医学主题项目将重点关注人类 微生物组肠道细菌与人体的相互作用是深刻的， 对维持一般人类健康的影响，但也与肥胖、炎症 疾病，糖尿病和某些癌症，仅举几例。JCSG将利用其HT平台， 通过广泛的生物物理，功能和生物医学影响，促进其所有结构的生物和生物医学影响。 与其他PSLBiology参与者合作进行生物信息学分析。因此，总体目标是 提供一个强大的，灵活的HT结构确定平台，将迎接挑战， 从PSLBiology伙伴关系和其他项目中产生的新机会 支持的项目。此外，我们将努力沿着PSI网络，以促进广泛使用 向一般科学界提供PSI资源、材料、方法、数据和模型。

The Joint Centerfor Structural Genomics (JCSG) aims to participate in the NIGMS PShBiology program as a Center for High-Throughput Structure Determination. The JCSG high-throughput (HT) platform assembled over the past ten years will efficiently deliver large numbers of protein structures to the community by both xray crystallography and NMR on a wide range of targets from bacteria to human, including challenging targets such as eukaryotic proteins, protein-protein and other macromolecular complexes. Throughout PSLBiology, the JCSG will adapt and tailor its operations to achieve the programmatic goals as they grow and evolve. The JCSG will continue to develop new technologies and methodologies, both experimental and computational, to address the spectrum of targets that will be presented, while keeping cost per structure to a minimum and quality to the highest standard. Integration within the PSI Network will be a high priority to embrace interactions with the Biology Partnership centers, future PARS, and the community, as well as support for all PSI Network activities, including the PSI-SGKB and PSI-MR. The JCSG will capitalize on its extensive experience to develop the best strategies to enhance chances of success and eliminate those that lead to failure. Contribution to the original PSI mission of extending structural coverage of the expanding protein universe will be advanced through judicious choice of targets, as will development of tools and collaborations that facilitate dissection of entire networks, pathways and molecular machineries for single organisms or cells from a structural perspective. The biomedical theme project will focus on the human microbiome. Interactions of commensal bacteria with the human body are profound and have a significant impact on maintenance of general human health, but are also associated with obesity, inflammatory diseases, diabetes and certain cancers to name but a few. The JCSG will leverage its HT platform to promote the biological and biomedical impact of all of its structures through extensive biophysical, functional and bioinformatics analyses in collaboration with the other PSLBiology participants. Thus, the overall goal is to provide a robust, flexible HT structure determination platform that will meet the challenges and embrace the new opportunities that arise from the projects emanating from the PSLBiology Partnerships and other PSI-supported projects. Furthermore, we will strive along with the PSI Network to promote widespread use of the PSI resources, materials, methodologies, data and models to the general scientific community.