Joint Center for Structural Genomics

结构基因组学联合中心(JCSG)的目标是作为 高吞吐量结构确定中心。组装的JCSG高通量(HT)平台 在过去的十年里，将通过x射线和x射线有效地向社区提供大量的蛋白质结构 从细菌到人类的广泛靶标的结晶学和核磁共振，包括具有挑战性的 靶标如真核蛋白质、蛋白质-蛋白质等大分子复合体。贯穿始终 PSLBiology，JCSG将调整和调整其业务，以实现随着方案目标的增长 并不断进化。JCSG将继续开发新的技术和方法，包括试验性和 计算性，以解决将提出的目标范围，同时保持每个结构的成本 以最低的标准和最高的质量。在PSI网络中的整合将是一个高度优先的 接受与生物合作伙伴中心、未来的PAR和社区以及 支持所有PSI网络活动，包括PSI-SGKB和PSI-MR。JCSG将利用其 丰富的经验，以制定最佳战略，以增加成功的机会，并消除 导致失败。对最初的防扩散安全倡议任务的贡献，即扩大扩大的结构覆盖面 蛋白质世界将通过明智地选择目标来推进，开发工具和 协作促进了对整个网络、路径和单个 从结构角度看的有机体或细胞。生物医学主题项目将聚焦于人类 微生物组。共生细菌与人体的相互作用是深刻的，并具有重要的 影响一般人的健康，但也与肥胖、炎症性有关 疾病、糖尿病和某些癌症，仅举几例。JCSG将利用其超线程平台来 通过广泛的生物物理、功能和功能促进其所有结构的生物和生物医学影响 与其他PSL生物学参与者合作进行生物信息学分析。因此，总体目标是 提供强大、灵活的HT结构确定平台，以迎接挑战并拥抱 从PSL生物学伙伴关系和其他项目中产生的新机会 PSI支持的项目。此外，我们将与PSI网络一起努力促进广泛使用PSI 向一般科学界提供防扩散安全倡议的资源、材料、方法、数据和模型。

The Joint Centerfor Structural Genomics (JCSG) aims to participate in the NIGMS PShBiology program as a Center for High-Throughput Structure Determination. The JCSG high-throughput (HT) platform assembled over the past ten years will efficiently deliver large numbers of protein structures to the community by both xray crystallography and NMR on a wide range of targets from bacteria to human, including challenging targets such as eukaryotic proteins, protein-protein and other macromolecular complexes. Throughout PSLBiology, the JCSG will adapt and tailor its operations to achieve the programmatic goals as they grow and evolve. The JCSG will continue to develop new technologies and methodologies, both experimental and computational, to address the spectrum of targets that will be presented, while keeping cost per structure to a minimum and quality to the highest standard. Integration within the PSI Network will be a high priority to embrace interactions with the Biology Partnership centers, future PARS, and the community, as well as support for all PSI Network activities, including the PSI-SGKB and PSI-MR. The JCSG will capitalize on its extensive experience to develop the best strategies to enhance chances of success and eliminate those that lead to failure. Contribution to the original PSI mission of extending structural coverage of the expanding protein universe will be advanced through judicious choice of targets, as will development of tools and collaborations that facilitate dissection of entire networks, pathways and molecular machineries for single organisms or cells from a structural perspective. The biomedical theme project will focus on the human microbiome. Interactions of commensal bacteria with the human body are profound and have a significant impact on maintenance of general human health, but are also associated with obesity, inflammatory diseases, diabetes and certain cancers to name but a few. The JCSG will leverage its HT platform to promote the biological and biomedical impact of all of its structures through extensive biophysical, functional and bioinformatics analyses in collaboration with the other PSLBiology participants. Thus, the overall goal is to provide a robust, flexible HT structure determination platform that will meet the challenges and embrace the new opportunities that arise from the projects emanating from the PSLBiology Partnerships and other PSI-supported projects. Furthermore, we will strive along with the PSI Network to promote widespread use of the PSI resources, materials, methodologies, data and models to the general scientific community.