University of Utah, Core Vision Research Grant

描述（申请人提供）：犹他大学的视觉研究有超过19名教职员工和60多名支持人员，研究生和博士后。这份关于视觉研究核心（VRC）拨款的提案将加强13名参与研究者的项目，他们共同拥有国家眼科研究所的16个R0l奖和1个R24奖。VRC由(1)影像学、(2)组学、(3)生理学和(3)生物化学模块组成，为参与研究者的项目提供全面的资源、培训和技术援助。这些程序由Moran Research数据中心集成，该数据中心的容量超过50tb，可扩展到500tb。成像模块提供：(1)超高速计算透射电子显微镜（TEM）成像服务；(2)激光共聚焦成像；(3)高分辨率、高速扫描光学成像；(4)光学、LSCM和EM数据的计算融合；(5)组织处理和超微切片服务；(7)丰富的成像软件库；(8)和企业级数据归档。组学模块提供：(1)基因分型服务；(2)胚胎、精子冷冻保存服务；(3)冷冻资源。生理学模块提供：(1)ERG视觉测试；(2)“OptoMotry”行为跟踪；(3) Heidelberg Spectralis OCT成像；(4)实时微米小鼠眼底成像。生物化学模块提供：(1)超离心；(2)蛋白定量（奥德赛成像）；(3)电穿孔;(4) HPLC/MS和GC/MS服务；(5) SensiQ表面等离子共振分子相互作用谱分析。

DESCRIPTION (provided by applicant): Vision research at the University of Utah engages over 19 faculty members and 60+ supporting staff, graduate students and postdoctoral fellows. This proposal for a Vision Research Core (VRC) Grant will enhance the programs of thirteen participating investigators who collectively hold sixteen R0l awards and one R24 award from the National Eye Institute. The VRC consists of (1) Imaging, (2) Histomics, (3) Physiology, and (3) Biochemistry modules, providing comprehensive resources, training and technical assistance to the programs of the participating investigators. These programs are integrated by a Moran Research data center with over 50 terabytes of capacity, expandable to 500 terabytes. The Imaging Module provides: (1) Ultra-speed computational transmission electron microscope (TEM) imaging services; (2) laser confocal imaging; (3) high-resolution, high-speed scanning optical imaging; (4) computational fusion of optical, LSCM, and EM data; (5) tissue processing and ultramicrotomy services; (7) extensive imaging software libraries; (8) and enterprise-scale data archiving. The Histomics Module provides: (1) Genotyping services; (2) Embryo and sperm cryopreservation services; and (3) Cryotomy resources. The Physiology Module provides: (1) ERG visual testing; (2) "OptoMotry" behavioral tracking; (3) Heidelberg Spectralis OCT imaging; and (4) Real-time Micron mouse fundus imaging. The Biochemistry Module provides: (1) Ultracentrifugation; (2) Protein quantification (Odyssey imaging); (3) Electroporation; (4) HPLC/MS and GC/MS services; (5) SensiQ surface plasmon resonance molecular interaction profiling. Access to both novel and established technologies, along with technical support, will facilitate collaborations, allow investigators to expand into new research avenues, enable new funding ventures, and enhance the educational experience of graduate students, medical students, interns, residents and postdoctoral fellows.