NHP Major Histocompatibility Complex Gene Discovery and Typing Technology

非人灵长类动物主要组织相容性复合体基因发现和分型技术开发的目标是通过基因发现和基因组表征研究，提供NHP MHC基因、位点和等位基因的详细知识，促进和加强非人灵长类动物（NHP）模型的免疫学研究；并通过开发和提供易于获得的手段或方法来对个体研究动物进行基因型，以获得完整的MHC等位基因，或选择等位基因，以优化实验设计和菌落遗传管理。国家卫生保健计划中MHC区域的详细地图将促进传染病、疫苗、移植和自身免疫性疾病的基础和临床研究，并支持该领域新工具和新技术的开发。

The objectives of Nonhuman Primate Major Histocompatibility Complex Gene Discovery and Typing Technology Development are to facilitate and enhance the immunological research conducted with the nonhuman primate (NHP) model by providing detailed knowledge of NHP MHC genes, loci and alleles through gene discovery and genomic characterization studies; and by developing and providing readily accessible means or methods to genotype individual research animals for the complete set of MHC alleles, or for select alleles, for the optimum design of experiments and genetic management of colonies. A detailed map of the MHC region in NHPs will promote basic and clinical research of infectious diseases, vaccines, transplantation, and autoimmune diseases, and support the development of new tools and techniques in this area.