NHP MHC Gene Discovery and Typing Technology Development

非人灵长类主要组织相容性复合体基因发现和分型技术开发的目标是通过基因发现和基因组特征研究提供关于NHP MHC基因、基因座和等位基因的详细知识，促进和加强利用非人灵长类模型进行的免疫学研究；开发和提供易于获得的手段或方法，为研究动物的完整MHC等位基因或选择等位基因分型，以优化实验设计和群体遗传管理。NHP中MHC区域的详细地图将促进传染病、疫苗、移植和自身免疫的基础和临床研究，并支持该领域新工具和技术的开发。

The objectives of Nonhuman Primate Major Histocompatibility Complex Gene Discovery and Typing Technology Development are to facilitate and enhance the immunological research conducted with the nonhuman primate model by providing detailed knowledge of NHP MHC genes, loci and alleles through gene discovery and genomic characterization studies; and by developing and providing readily accessible means or methods to genotype individual research animals for the complete set of MHC alleles, or for select alleles, for the optimum design of experiments and genetic management of colonies. A detailed map of the MHC region in NHPs will promote basic and clinical research of infectious diseases, vaccines, transplantation, and autoimmunity, and support the development of new tools and techniques in this area.