Systems Approach to Immunity and Inflammation
Systems Approach to Immunity and Inflammation
批准号:
8277180
负责人:
Richard J Ulevitch
金额:
$1087.94万
依托单位国家:
美国
项目类别:
财政年份:
2007
资助国家:
美国
项目状态:
已结题
起止时间:
2007-08-31 至 2012-08-30
关键词:
AgonistBioinformaticsBiologicalBiological AssayCD8B1 geneCategoriesCell Surface ProteinsCellsCommunitiesComputational BiologyComputer AnalysisContractsCorrelation StudiesDataDefectDisease susceptibilityDominant-Negative MutationEctromeliaEthylnitrosoureaEventFrancisellaGene Expression ProfileGenesGeneticGenomicsGoalsGram-Negative BacteriaHumanImmuneImmune Response GenesImmune responseImmunityImmunogeneticsIn VitroInflammationInfluenzaInformaticsKineticsListeriaLocationMonoclonal AntibodiesMusNational Institute of Allergy and Infectious DiseaseOnline SystemsPhosphorylationProductionProteinsProteomicsRNA InterferenceReagentRecombinantsRegulator GenesResistanceSalmonellaSamplingSignal TransductionSupport SystemSystemSystems BiologyTissuesbasedata managementdata portalgenome-widehigh throughput screeningin vivomouse modelnovelpathogenprogramsresponsetranscription factor
中文摘要
该计划的目标是支持先天和/或适应性免疫反应的系统生物学分析,重点是NIAID A类,B和C类优先病原体。该分析将基于现有或新型小鼠模型的高通量筛选,以识别关键的调节免疫反应基因,并得到详细的基因组学,蛋白质组学,计算生物学和生物信息学方法的支持,以确定基因产物的功能。将使用人细胞或组织对小鼠中鉴定的免疫调节基因子集进行人体相关性研究。
英文摘要
The goal of this program is to support systems biology analyses of innate and/or adaptive immune responses, with a focus on NIAID Category A, B, and C priority pathogens. The analysis will be based on high-throughput screens of existing or novel mouse models for identification of key regulatory immune response genes, supported by detailed genomics, proteomics, computational biology, and bioinformatics approaches to determine the gene products' functions. Human correlation studies will be performed on a subset of the immune regulatory genes identified in the mouse using human cells or tissues.
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Systems Approach to Immunity and Inflammation
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批准号:10242980
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项目类别:
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资助金额:$47.2万
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财政年份:2020
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负责人:Richard J Ulevitch
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依托单位:
Systems Approach to Immunity and Inflammation
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批准号:10159667
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项目类别:
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资助金额:$36.66万
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财政年份:2020
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负责人:Richard J Ulevitch
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依托单位:
Systems Approach to Immunity and Inflammation
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批准号:10291571
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项目类别:
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资助金额:$188.73万
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财政年份:2020
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负责人:Richard J Ulevitch
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依托单位:
Human Correlation Core
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批准号:10181123
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项目类别:
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资助金额:$15.14万
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财政年份:2020
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负责人:Richard J Ulevitch
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依托单位:
Systems Approach to Immunity and Inflammation
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批准号:10189749
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项目类别:
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资助金额:$83.86万
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财政年份:2020
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负责人:Richard J Ulevitch
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依托单位:
Systems Approach to Immunity and Inflammation
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批准号:8717568
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项目类别:
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资助金额:$633.95万
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财政年份:2012
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负责人:Richard J Ulevitch
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依托单位:
Systems Approach to Immunity and Inflammation
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批准号:9767005
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项目类别:
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资助金额:$221.33万
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财政年份:2012
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负责人:Richard J Ulevitch
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依托单位:
Human Correlation Core
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批准号:10240686
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项目类别:
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资助金额:$34.93万
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财政年份:2012
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负责人:Richard J Ulevitch
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依托单位:
Systems Approach to Immunity and Inflammation
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批准号:8523781
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项目类别:
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资助金额:$616.69万
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财政年份:2012
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负责人:Richard J Ulevitch
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依托单位:
Systems Approach to Immunity and Inflammation
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批准号:8893876
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项目类别:
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资助金额:$632.44万
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财政年份:2012
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负责人:Richard J Ulevitch
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依托单位:
Systems Approach to Immunity and Inflammation
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批准号:9117401
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项目类别:
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资助金额:$803.35万
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财政年份:2012
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负责人:Richard J Ulevitch
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依托单位:
Administrative Core
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批准号:10240684
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项目类别:
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资助金额:$25.75万
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财政年份:2012
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负责人:Richard J Ulevitch
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依托单位:
Systems Approach to Immunity and Inflammation
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批准号:8326361
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项目类别:
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资助金额:$635.77万
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财政年份:2012
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负责人:Richard J Ulevitch
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依托单位:
Systems Approach to Immunity and Inflammation
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批准号:10240683
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项目类别:
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资助金额:$220.14万
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财政年份:2012
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负责人:Richard J Ulevitch
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依托单位:
Systems Approach to Immunity and Inflammation
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批准号:10395064
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项目类别:
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资助金额:$30.29万
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财政年份:2012
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负责人:Richard J Ulevitch
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依托单位:
Systems Approach to Innate Immunity-Inflammation-Sepsis
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批准号:6784636
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项目类别:
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资助金额:$538.98万
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财政年份:2002
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负责人:Richard J Ulevitch
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依托单位:
Systems Approach to Innate Immunity-Inflammation-Sepsis
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批准号:6663192
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项目类别:
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资助金额:$476.98万
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财政年份:2002
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负责人:Richard J Ulevitch
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依托单位:
Systems Approach to Innate Immunity-Inflammation-Sepsis
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批准号:7107953
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项目类别:
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资助金额:$635.94万
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财政年份:2002
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负责人:Richard J Ulevitch
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依托单位:
Systems Approach to Innate Immunity-Inflammation-Sepsis
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批准号:6555146
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项目类别:
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资助金额:$482.18万
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财政年份:2002
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负责人:Richard J Ulevitch
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依托单位:
Systems Approach to Innate Immunity-Inflammation-Sepsis
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批准号:6937206
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项目类别:
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资助金额:$661.83万
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财政年份:2002
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负责人:Richard J Ulevitch
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依托单位:
海外基金