Career Development and Mentoring in Clinical/Translational Alcohol Research

高级科学家研究和导师奖的目标是“杰出的高级科学家， 已经证明了持续的高生产力水平进行生物医学研究”，以保护 他们有时间继续研究，同时指导下一代研究人员。拥有20多年 临床酒精研究经验[超过20项临床试验，渴望（OCDS）的开创性工作，生物标志物 饮酒（CDT）和神经影像学]，15年的持续R 01资助，12年的科学服务， 酒精研究中心主任，180篇同行评审的出版物，国际认可， 候选人符合杰出高级科学家的要求。他被选为高级 领导地位的领先的学术和研究学会，担任同行选举的主席， 指导委员会，指导大型，多中心NIH/NIAAA资助的临床试验（联合收割机研究）， 研究了1383名酒精依赖者，并因其独特的技能而被视为专家， 知识和能力，以弥合基础和临床研究之间的差距。他做到了这一点 同时在酒精研究方面保持积极的培训计划，包括20年的董事或共同 NIAAA赞助的T32研究培训补助金的主任。他指导了17名专业人士（12名医学博士 和5个博士学位），许多人因为他在基础和临床科学方面的专业知识而找到他，许多人 已经获得了独立的酒精研究资金，所有仍然与酒精领域联系在一起的人。他 对酒精障碍的治疗机制和应用的理解是不典型的 也很特别这个奖项对候选人很重要，主要有两个原因：第一，它将为他提供 有保护的时间，以保持他的酒精研究事业的前沿，使他能够获得正式的 以及遗传学和蛋白质组学的非正式培训（课程详情见职业计划）， 科学的基本领域，他自己的酒精研究（如概述），并交流新的发现， 酒精治疗领域。其次，该奖项将为候选人提供受保护的时间， 额外的临床和行政职责，以便他可以继续并扩大他的积极指导 该计划的重点是下一代临床科学家的发展。知识 他从培训中获得的技能将融入并加强他的指导计划。 随着医学研究所和美国医学院协会强调大， 美国对临床和转化研究人员的需求未得到满足，数百万美国人患有 酒精障碍，谁是服务不足，谁花费美国经济1800亿美元，每年，有一个 我们需要推动临床研究向前发展，需要确保我们的高级科学家在他们的研究领域处于最前沿。 研究，并需要培训未来的科学家进行这项研究，以找到有效的治疗方法。K05 高级科学家职业和指导奖将允许这种情况发生。

The Senior Scientist Research and Mentorship Award is targeted for "outstanding senior scientists who have demonstrated a sustained level of high productivity conducting biomedical research" in order to protect their time to continue research while mentoring the next generation of investigators. With more than 20 years of experience in clinical alcohol research [over 20 clinical trials, seminal work in craving (OCDS), biomarkers of drinking (CDT), and neuroimaging], 15 years of continued R01 funding, 12 years of serving as Scientific Director of an Alcohol Research Center, 180 peer reviewed publications, and international recognition, the candidate meets the requirements as an outstanding senior scientist. He has been elected to high leadership positions of leading academic and research societies, serves as the peer-elected chairman of the steering committee, directing the large, multi-center NIH/NIAAA funded clinical trial (COMBINE Study) which studied 1383alcohol dependent individuals, and is sought out as an expert for his unique skillset, knowledge and ability to bridge the gap between basic and clinical research. He has accomplished this while maintaining an active training program in alcohol research, including 20 years as Director or Co- Director of an NIAAA-sponsored T32 Research Training Grant. He has mentored 17 professionals (12 MDs & 5 PhDs), many who sought him out due to his expertise in bridging basic and clinical science, many who have secured independent alcohol research funding, and all who remain tied to the alcohol field. His understanding of both the mechanisms of, and applications to, the treatment of alcohol disorders is atypical and exceptional. This award is important to the candidate for two major reasons: First, it will provide him with protected time to keep his alcohol research career on the cutting edge by enabling him to obtain formal and informal training in genetics and proteomics (course details provided in the career plan), apply these essential areas of science to his own alcohol research (as outlined), and communicate new discoveries to the alcohol treatment field in general. Second, this award will provide the candidate with protected time from additional clinical and administrative duties so he can continue with and expand his active mentoring program which is focused on the development of the next generation of clinical scientists. The knowledge and skills he gains from his training will be integrated into and strengthen his mentoring program. With the Institute of Medicine and the American Association of Medical Colleges highlighting the large, unmet need in the US for clinical and translational researchers and with millions of Americans suffering from alcohol disorders, who are underserved and who cost the US economy $180 billion each year, there is a need to push clinical research forward, a need to ensure our senior scientists are on the cutting edge in their research, and a need to train future scientists to carry on this research to find effective treatments. This K05 Senior Scientist Career and Mentoring Award will allow this to happen.