Career Support and Mentoring of Interdisciplinary Alcohol Research

描述（由申请人提供）：获得高级科学家研究和指导奖（KO5），候选人将为3- 5名对跨学科酒精研究感兴趣的教师提供指导。初涉酒类领域的初级教员或受过专业训练的教员将优先考虑。候选人已经在酒精领域拥有成功指导和科学领导的持续记录。指导将包括资助写作和其他技能的指导，他们的研究项目的发展，专业发展以及如何有效地在跨学科团队中工作。为了保持候选人作为科学领导者的表现，候选人将继续在耶鲁大学和全国范围内进行广泛的跨学科研究合作。持续的科学增长将受益于与研究指导、参与研究审查和咨询小组参与有关的活动。此外，PI将通过心理治疗干预、药物治疗发展和人类生物行为实验室研究的临床研究，继续为酒精中毒领域做出贡献。本研究计划将考虑酒精和烟草使用的相互影响。例如，该研究计划提出了一项R01资助的关于纳曲酮和BASICS咨询以减少18-25岁年轻人酗酒的研究。本研究整合了来自基础研究、人体实验室研究、调查研究和临床试验的纳曲酮信息，以优化其对接受简短咨询以激励和教授减少饮酒技能的年轻人的使用。纳曲酮在这一人群中的有效性证明将为大学咨询中心和其他致力于降低年轻人酗酒风险的医疗机构采用纳曲酮提供必要的信息。最终，在这个关键时期的早期意图可能会通过改变饮酒轨迹而产生长期的好处。未来的研究计划包括对现有临床试验进行二次分析，利用人体实验室范例筛选治疗酒精依赖的新药物，以及对有希望的化合物进行临床试验。

DESCRIPTION (provided by applicant): With this Senior Scientist Research and Mentorship Award (KO5), the Candidate will provide mentorship to 3- 5 faculty interested in interdisciplinary alcohol research. Preference will be given to junior faculty or faculty with strong disciplinary training who are new to the alcohol area. The Candidate already has a sustained track record of successful mentorship and scientific leadership in the alcohol field. Mentorship will include guidance on grant writing and other skills, the development of their research program, professional development and how to effectively work within interdisciplinary teams. In order to sustain the Candidate's performance as a scientific leader, the Candidate will continue extensive collaborations in interdisciplinary research at Yale University and nationally. Continued scientific growth will benefit from activities related to research mentoring and participation in research review and advisory group participation. Additionally, the PI will continue her contributions to the alcoholism field through clinical research on psychotherapeutic interventions, pharmacotherapy development, and human bio-behavioral laboratory studies. The reciprocal influence of alcohol and tobacco use will be considered in this program of research. As an example, the research plan presents a R01 funded study of naltrexone and BASICS counseling to reduce heavy drinking by young adults ages 18-25. This study integrates information on naltrexone derived from basic research, human laboratory studies, survey studies, and clinical trials to optimize its use for young adults who receive brief counseling to motivate and teach skills for reducing their drinking. Demonstration of the efficacy of naltrexone in this population will provide the essential information for its adoption by college counseling centers and other health care settings committed to reducing the risk of heavy drinking in young adults. Ultimately, early intention during this critical period may have long term benefits by altering trajectories of drinking. Plans for future research include secondary analyses of existing clinical trials, using human laboratory paradigms to screen new medications for alcohol dependence and clinical trials of promising compounds. PUBLIC HEALTH RELEVANCE: An interdisciplinary approach to understanding and addressing hazardous alcohol use and alcohol dependence has the potential to substantially improve the effectiveness of prevention and treatment of alcohol dependence. This award will help train new investigators in interdisciplinary alcohol research.