Genetic and epigenetic controls of gene regulation

描述（由申请人提供）：我们建议开发统计和计算方法来解释来自ENCODE项目的各种细胞类型的基因调控数据。我们的工作将集中在(i)开发整合许多组织中不同数据类型的方法，以推断染色质结构；（ii）推断不同细胞类型间染色质差异的序列决定因素和调控后果；（三）利用自然遗传变异和实验方法对我们的预测进行实证检验。

DESCRIPTION (provided by applicant): We propose to develop statistical and computational methods for interpreting data on gene regulation in a variety of cell types from the ENCODE Project. Our work will focus on (i) developing methods for integrating diverse data types in many tissues to infer chromatin architecture; (ii) inferring the sequence determinants and regulatory consequences of differences in chromatin across cell types; and (iii) empirical tests of our predictions using both natural genetic variation and experimental approaches. PUBLIC HEALTH RELEVANCE: The purpose of this project is to develop new statistical and computational tools for analyzing and interpreting data from the ENCODE project. These data relate to the controls of gene regulation in a wide variety of cell types.