NEIBank: Est Analysis And Bioinformatics For Ocular Genomics

许多人的眼睛（和耳朵）组织和重要的动物模型的组织现在已经被分析。此外，NEIBank的合作项目还增加了其他感觉组织、耳朵和味蕾的数据。最近增加的眼睛包括人视神经和人翼状胬肉。该DNA资源已被用于创建含有13,000个非冗余人眼表达序列和6500个小鼠眼睛序列的cDNA微阵列。这些被用于分析人类细胞反应和转基因小鼠模型。

Many human eye (and also ear) tissues and those of important animal models have now been analyzed. In addition NEIBank collaborations have added data on other sensory tissues, ear and taste bud. Recent eye additions include human optic nerve and human pterygium. This DNA resource has been used to create cDNA microarrays with 13,000 non-redundant human eye expressed sequences and 6500 sequences from mouse eye. These are being used in analysis of human cellular responses and genetically modified mouse models. A powerful addition to the informatics tools for eye research is EyeBrowse, a dedicated genome browser for eye-expressed genes, produced in collaboration with CIT. http://eyebrowse.cit.nih.gov/genome/. Major additions are a unique annotated database of human eye disease genes and databases of candidate eye disease regions of the genome. These are displayed in EyeBrowse along with all known human eye-derived cDNAs and SAGE data, indicating expression profiles specific to eye. A recent addition is a track for SAGE data for human Trabecular Meshwork with relevance to glaucoma. NEIBank analyses provide detailed insights into the expression of genes in eye tissues of several important animal models. Most recently this includes data on the ground squirrel retina, which is a model for a cone-related function and disease in human eye. Data from this analysis are being used to design a custom microarray for future experiments.