Role of Innate and Adaptive Immune Systems in Drug-Induced Liver Disease

去年，我们发现，氟烷治疗后，调节性T细胞渗入雌性Balb/CJ小鼠的肝脏，并抑制了针对氟烷治疗后体内形成的三氟乙酰化蛋白的体液和细胞免疫反应。今年，我们报告了新发现的髓系来源的抑制细胞在氟烷治疗后也渗透到雌性Balb/CJ小鼠的肝脏。这些细胞最近被证明在肿瘤、感染和自身免疫性疾病中抑制效应器T细胞的活性。 结论：调节性T细胞和髓系抑制细胞可能在适应性免疫系统介导的药物-蛋白加合物引起的肝损伤中发挥作用，这些调节性细胞的活性缺陷可能是DILD的易感因素。

Last year we found that regulatory T cells infiltrated into the liver of female Balb/cJ mice following halothane treatment and inhibited both humoral and cellular immune reactions against trifluoroacetylated proteins formed in vivo following halothane treatment. This year we report that newly discovered myeloid-derived suppressor cells also infiltrated into the liver of female Balb/cJ mice following halothane treatment. These cells have be shown recently to inhibit effector T cell activity in tumors, infections, and in autoimmune diseases. Conclusion: These findings suggest that both regulatory T cells and myeloid-derived suppressor cells might have a role in preventing drug-protein adducts from causing liver injury mediated by the adaptive immune system and that deficiencies in the activities of these regulatory cells might be susceptibility factors in DILD.