Joint Center for Structural Genomics

结构基因组学联合中心(JCSG)的目标是作为高通量结构确定中心参与NIGMS PSI：生物学计划。过去十年组装的JCSG高通量(HT)平台将通过X射线结晶学和核磁共振在从细菌到人类的广泛目标上高效地向社区交付大量蛋白质结构，包括具有挑战性的目标，如真核蛋白质、蛋白质-蛋白质和其他大分子复合体。在整个PSI：生物学中，JCSG将适应和定制其操作，以实现随着它们的成长和发展而产生的计划目标。JCSG将继续开发新的技术和方法，包括实验和计算，以解决将提出的目标范围，同时将每个结构的成本保持在最低水平，并将质量保持在最高标准。在PSI网络内的整合将是一个高度优先事项，以包括与生物伙伴关系中心、未来的PAR和社区的互动，以及对所有PSI网络活动的支持，包括PSI-SGKB和PSI-MR。JCSG将利用其丰富的经验，制定最佳战略，以增加成功的机会，消除导致失败的战略。PSI最初的使命是扩大不断扩大的蛋白质宇宙的结构覆盖范围，这一使命的贡献将通过明智地选择目标来推进，开发工具和合作将促进从结构角度剖析单个生物体或细胞的整个网络、途径和分子机制。生物医学主题项目将以人类微生物群为重点。共生细菌与人体的相互作用是深刻的，对维持一般人类健康有重大影响，但也与肥胖、炎症性疾病、糖尿病和某些癌症有关，仅举几例。JCSG将利用其HT平台，与其他PSI：生物学参与者合作，通过广泛的生物物理、功能和生物信息学分析，促进其所有结构的生物和生物医学影响。因此，总体目标是提供一个强大、灵活的HTS结构确定平台，该平台将迎接挑战并抓住由PSI：生物伙伴关系和其他PSI支持的项目产生的新机遇。此外，我们将与防扩散安全倡议网络一道，努力促进向一般科学界广泛使用防扩散安全倡议的资源、材料、方法、数据和模型。

The Joint Center for Structural Genomics (JCSG) aims to participate in the NIGMS PSI:Biology program as a Center for High-Throughput Structure Determination. The JCSG high-throughput (HT) platform assembled over the past ten years will efficiently deliver large numbers of protein structures to the community by both x-ray crystallography and NMR on a wide range of targets from bacteria to human, including challenging targets such as eukaryotic proteins, protein-protein and other macromolecular complexes. Throughout PSI:Biology, the JCSG will adapt and tailor its operations to achieve the programmatic goals as they grow and evolve. The JCSG will continue to develop new technologies and methodologies, both experimental and computational, to address the spectrum of targets that will be presented, while keeping cost per structure to a minimum and quality to the highest standard. Integration within the PSI Network will be a high priority to embrace interactions with the Biology Partnership centers, future PARS, and the community, as well as support for all PSI Network activities, including the PSI-SGKB and PSI-MR. The JCSG will capitalize on its extensive experience to develop the best strategies to enhance chances of success and eliminate those that lead to failure. Contribution to the original PSI mission of extending structural coverage of the expanding protein universe will be advanced through judicious choice of targets, as will development of tools and collaborations that facilitate dissection of entire networks, pathways and molecular machineries for single organisms or cells from a structural perspective. The biomedical theme project will focus on the human microbiome. Interactions of commensal bacteria with the human body are profound and have a significant impact on maintenance of general human health, but are also associated with obesity, inflammatory diseases, diabetes and certain cancers to name but a few. The JCSG will leverage its HT platform to promote the biological and biomedical impact of all of its structures through extensive biophysical, functional and bioinformatics analyses in collaboration with the other PSI:Biology participants. Thus, the overall goal is to provide a robust, flexible HT structure determination platform that will meet the challenges and embrace the new opportunities that arise from the projects emanating from the PSI:Biology Partnerships and other PSI-supported projects. Furthermore, we will strive along with the PSI Network to promote widespread use of the PSI resources, materials, methodologies, data and models to the general scientific community.