Developmental Determinants of Cardiovascular Disease

描述(由申请人提供)：这是一份新的T32申请，来自范德比尔特大学医学院儿科心脏病学部和小门罗·卡瑞尔。范德比尔特儿童医院。我们的长期目标是在该司在培训儿科学术心脏病专家方面取得成功的基础上，制定一项计划，将心血管疾病发育决定因素研究的正式培训与儿科心脏病学的临床培训相结合。这一培训计划不仅将重点放在先天性心脏病的分子和遗传病因上，还将强调出生前和出生后发育在确定儿童心血管疾病出生后表现方面的影响。除了儿科心脏病学的实习生外，相关儿科专科的临床研究员，如肺医学、重症监护医学和新生儿学，以及对研究心血管疾病的发展机制表示兴趣的博士后研究员，将有资格获得支持。本课程将为受训者提供一个独特的机会，学习在儿童或成年后期出现的心血管病理个体发生中的正常发育过程的重述。该计划将由两个轨道组成，为(1)基础科学研究或(2)临床或转化性研究进行优化。有针对性的教学互动的重点实验室体验将被量身定做，以满足那些追求更基础科学职业的人的需求。对于寻求临床或转化医学职业生涯的学员，范德比尔特临床调查理学硕士(MSCI)计划将是培训计划不可或缺的一部分。候选人将主要从儿科心脏病研究金的申请者中挑选(2010年有102名申请者申请2个职位)。这项提议将为第二年和第三年的奖学金提供资金，在此期间，受训者将进行指导研究。在第四年，学员将完成临床培训，并可选择在子专科进行高级培训，以及继续研究和提交K08或K23申请。新闻部和该司承诺为这项培训的第一年和第四年提供资金。项目主任将使用一个由Vanderbilt内部成功的内科科学家组成的内部咨询委员会和一个外部咨询委员会，该委员会包括临床和基础研究专家，他们也是目前儿科心脏病学T32应用的项目主任。利用范德比尔特大学在发育生物学、血管生物学、再生医学和组织工程、心血管药理学和药物遗传学以及基于人口和结果的研究领域的独特优势，该项目将有助于培养下一代内科科学家。通过将以前的实习生纳入培训导师，该计划将帮助这些初级教员在他们的学术生涯中，并为该计划未来的成功保持一支导师队伍。

DESCRIPTION (provided by applicant): This is a new T32 application from the Division of Pediatric Cardiology of the Department of Pediatrics, Vanderbilt University School of Medicine and the Monroe Carell Jr. Children's Hospital at Vanderbilt. Our long- term goal is to build upon the success of the Division in training academic pediatric cardiologists by developing a program that integrates formal training in research on developmental determinants of cardiovascular disease with clinical training in pediatric cardiology. This training program will not only focus on the molecular and genetic etiologies of congenital heart disease, but will also emphasize the impact of pre- and postnatal development in defining the manifestations of pediatric cardiovascular disease after birth. In addition to trainees in the Pediatric Cardiology, clinical fellows in related Pediatric subspecialties such as Pulmonary Medicine, Critical Care Medicine, and Neonatology as well as Ph.D. post-doctoral fellows who have an expressed interest in investigating development mechanisms of cardiovascular disease will be eligible for support. This program will provide a unique opportunity for trainees to study the recapitulation of normal developmental processes in the ontogeny of cardiovascular pathology presenting later in childhood or adulthood. The program will be composed of two tracks optimized either for pursuit of preparation for (1) basic science investigation or (2) clinical or translational research. A focused laboratory experience with targeted didactic interactions will be tailored to meet the needs of those pursing a more basic science career. For trainees pursuing a career in clinical or translational medicine, the Vanderbilt Master of Science in Clinical Investigation (MSCI) program will be an integral part of the training program. Candidates will primarily be identified from the pool of applicants for pediatric cardiology fellowship (102 applicants for 2 positions in 2010). This proposal will fund the second and third years of fellowship, during which the trainee will carry out the mentored research. During the fourth year, the trainee will complete clinical training with the option of advanced training in a sub-subspecialty as well as continued research and submission of a K08 or K23 application. The Department and Division are committed to funding the first and fourth years of this training. The program directors will use an internal advisory committee, comprised of successful physician-scientists from within Vanderbilt, as well as an external advisory committee that includes experts in both clinical and basic research who are also program directors for current T32 applications in Pediatric Cardiology. Using the unique strengths of Vanderbilt University in the areas of developmental biology, vascular biology, regenerative medicine and tissue engineering, cardiovascular pharmacology and pharmacogenetics, and population as well as outcomes based research, the program will help train the next generation of physician scientists. By including former trainees as Mentors-in-training, the program will assist these junior faculty members in their academic careers as well as maintain a cadre of mentors for the future success of this program.