BIOMEDICAL (APPLIED/EXPLORATORY)

疾病相关基因的发现需要具有遗传变异的个体群体以及对照（未受影响的）个体群体。因此，一个遗传物质的储存库，包括DNA样本、冷冻保存的淋巴细胞、永生化细胞系以及伴随的临床和谱系数据，对于研究与NIDDK的使命相关的疾病的研究界来说，显然是一个宝贵的资源。这个项目，这将被称为"遗传学知识库“，继续在2003年开始的一个重要的收集，并在概念上与在NIH的其他研究所现有的知识库。该储存库将允许继续存储，维护和质量控制，以及公平，道德地分配DNA和其他对NIDDK任务下的疾病研究至关重要的资源。它促进了资源的共享，从而鼓励了广泛的研究人员的工作，并可能增加样本量，从而提高研究确定疾病遗传决定因素的能力。它有助于确保研究参与者将作出最大贡献，并减少重复抽样工作。

Discovery of disease related genes requires a population of individuals with the genetic variant, as well as a population of control (unaffected) individuals. Thus, a repository of genetic materials, including DNA samples, cryopreserved lymphocytes, immortalized cell lines, and accompanying clinical and pedigree data is clearly an invaluable resource for the research community studying diseases related to the mission of the NIDDK. This project, which will be referred to herein as ¿The Genetics Repository¿, continues an important collection begun in 2003 and is conceptually related to repositories in existence at other institutes at the NIH. The repository will allow the continued storage, maintenance, and quality control, and equitable, ethical distribution of DNA and other resources important to the study of diseases under the mandate of the NIDDK. It facilitates sharing of resources, thus encouraging work by a broad group of investigators and, perhaps, increasing the sample size and the resulting power of a study to identify genetic determinants of a disease. It helps to ensure that research participants will be making a maximal contribution, and decreases duplicative sampling efforts.